An Automated and Accurate Methodology to Assess Ki-67 Labeling Index of Immunohistochemical Staining Images of Breast Cancer Tissues

Salar Razavi, Fariba D. Khameneh, Ercan Alp Serteli, Sercan Cayir, Sukru Burak Cetin, Gokhan Hatipoglu, Samet Ayalti, Mustafa Kamasak

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5 Atıf (Scopus)

Özet

Automatic scoring of Ki-67 with digital image analysis would improve the accuracy of the diagnostic. However, automatic Ki-67 assessment is very challenging due to complex variations of cell characteristics. In this paper, we propose an integrated framework for accurate Ki-67 scoring. The main contributions of our method are: a robust cell detection algorithm to detect all tumor and non-tumor cells; a clustering model for computerized classification of tumor and non-tumor cells and subsequent proliferation rate scoring by quantifying Ki-67, based on classified cells which appear in breast cancer immunohistochemical images. Unlike existing Ki-67 scoring techniques, our methodology works on whole slide images (WSI) using patches that are extracted from detected tissues. As the size of each sample is so large they can not be handled as a single image. Therefore, each slide is divided into small parts and on edge tiles merging is considered to preserve the continuity of nuclei. The proposed method has been extensively evaluated on tissue microarray (TMA) whole slides, and the cell detection performance is comparable to manual annotations and is very accurate compared with the estimation of an experienced pathologist.

Orijinal dilİngilizce
Ana bilgisayar yayını başlığıProceedings - 2018 25th International Conference on Systems, Signals and Image Processing, IWSSIP 2018
EditörlerAles Zamuda, Peter Planinsic, Dusan Gleich
YayınlayanIEEE Computer Society
ISBN (Basılı)9781538669792
DOI'lar
Yayın durumuYayınlandı - 17 Ağu 2018
Harici olarak yayınlandıEvet
Etkinlik25th International Conference on Systems, Signals and Image Processing, IWSSIP 2018 - Maribor, Slovenia
Süre: 20 Haz 201822 Haz 2018

Yayın serisi

AdıInternational Conference on Systems, Signals, and Image Processing
Hacim2018-June
ISSN (Basılı)2157-8672
ISSN (Elektronik)2157-8702

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???event.eventtypes.event.conference???25th International Conference on Systems, Signals and Image Processing, IWSSIP 2018
Ülke/BölgeSlovenia
ŞehirMaribor
Periyot20/06/1822/06/18

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Publisher Copyright:
© 2018 IEEE.

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