A simple spectrophotometric procedure for determination of valaciclovir in dosage forms and biological fluids

Derya Tarinc; Aysegul Golcu

doi:10.1134/S106193481301005X

A simple spectrophotometric procedure for determination of valaciclovir in dosage forms and biological fluids

Derya Tarinc^*
, Aysegul Golcu

^*Bu çalışma için yazışmadan sorumlu yazar

Kahramanmaras Sutcu Imam University

Araştırma çıktısı: Dergi yayını › Makale › Hakem

8 Atıf (Scopus)

Özet

A simple and selective spectrophotometric procedure for the determination of Valaciclovir (VALA) is proposed and applied to determine the substance in tablets and biological fluids. This procedure is proposed for the determination of VALA in Britton-Robinson (BR) buffer at pH 6.0, which allows quantification over the 4 × 10^-6 to 6 × 10^-5 M range for spectrophotometric measurements. The repeatability and reproducibilty of the procedure for serum and breast milk samples are estimated. Precision and accuracy are also checked. The standard additions method is used for biological fluids. The proposed produce was verified for the determination of VALA in real human serum, breast milk samples; the selectivity over the metabolites was found to be quite satisfactory.

Orijinal dil	İngilizce
Sayfa (başlangıç-bitiş)	27-32
Sayfa sayısı	6
Dergi	Journal of Analytical Chemistry
Hacim	68
Basın numarası	1
DOI'lar	https://doi.org/10.1134/S106193481301005X
Yayın durumu	Yayınlandı - Oca 2013
Harici olarak yayınlandı	Evet

Finansman

This research was supported by a grant TUBITAK (grant no. 109T020) for Assoc. Prof. Dr. Aysegul Golcu. The authors gratefully acknowledge the funding of this work by the Research Fund (project no. 2009/3 10) of Kahramanmara¸s Sütçü I·mam University, Kahraman mara¸s, Turkey.

Finansörler	Finansör numarası
Kahramanmara¸s Sütçü I·mam University
TUBITAK	109T020

Belgeye Erişim

10.1134/S106193481301005X

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Link to publication in Scopus

Alıntı Yap

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abstract = "A simple and selective spectrophotometric procedure for the determination of Valaciclovir (VALA) is proposed and applied to determine the substance in tablets and biological fluids. This procedure is proposed for the determination of VALA in Britton-Robinson (BR) buffer at pH 6.0, which allows quantification over the 4 × 10-6 to 6 × 10-5 M range for spectrophotometric measurements. The repeatability and reproducibilty of the procedure for serum and breast milk samples are estimated. Precision and accuracy are also checked. The standard additions method is used for biological fluids. The proposed produce was verified for the determination of VALA in real human serum, breast milk samples; the selectivity over the metabolites was found to be quite satisfactory.",

keywords = "biological fluids, spectrophotometry",

author = "Derya Tarinc and Aysegul Golcu",

year = "2013",

month = jan,

doi = "10.1134/S106193481301005X",

language = "English",

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journal = "Journal of Analytical Chemistry",

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T1 - A simple spectrophotometric procedure for determination of valaciclovir in dosage forms and biological fluids

AU - Tarinc, Derya

AU - Golcu, Aysegul

PY - 2013/1

Y1 - 2013/1

N2 - A simple and selective spectrophotometric procedure for the determination of Valaciclovir (VALA) is proposed and applied to determine the substance in tablets and biological fluids. This procedure is proposed for the determination of VALA in Britton-Robinson (BR) buffer at pH 6.0, which allows quantification over the 4 × 10-6 to 6 × 10-5 M range for spectrophotometric measurements. The repeatability and reproducibilty of the procedure for serum and breast milk samples are estimated. Precision and accuracy are also checked. The standard additions method is used for biological fluids. The proposed produce was verified for the determination of VALA in real human serum, breast milk samples; the selectivity over the metabolites was found to be quite satisfactory.

AB - A simple and selective spectrophotometric procedure for the determination of Valaciclovir (VALA) is proposed and applied to determine the substance in tablets and biological fluids. This procedure is proposed for the determination of VALA in Britton-Robinson (BR) buffer at pH 6.0, which allows quantification over the 4 × 10-6 to 6 × 10-5 M range for spectrophotometric measurements. The repeatability and reproducibilty of the procedure for serum and breast milk samples are estimated. Precision and accuracy are also checked. The standard additions method is used for biological fluids. The proposed produce was verified for the determination of VALA in real human serum, breast milk samples; the selectivity over the metabolites was found to be quite satisfactory.

KW - biological fluids

KW - spectrophotometry

UR - https://www.scopus.com/pages/publications/84871776665

U2 - 10.1134/S106193481301005X

DO - 10.1134/S106193481301005X

M3 - Article

AN - SCOPUS:84871776665

SN - 1061-9348

VL - 68

SP - 27

EP - 32

JO - Journal of Analytical Chemistry

JF - Journal of Analytical Chemistry

IS - 1

ER -

A simple spectrophotometric procedure for determination of valaciclovir in dosage forms and biological fluids

Özet

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Belgeye Erişim

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