A novel thienothiophene-based “dual-responsive” probe for rapid, selective and sensitive detection of hypochlorite

Garen Suna, Eda Erdemir, Lokman Liv, Aysenur Cataler Karakus, Dilara Gunturkun, Turan Ozturk*, Erman Karakuş*

*Bu çalışma için yazışmadan sorumlu yazar

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7 Atıf (Scopus)

Özet

Background: Hypochlorite/hypochlorous acid (ClO/HOCl) is a biologically crucial reactive oxygen species (ROS), produced in living organisms and has a critical role as an antimicrobial agent in the natural defense system. However, when ClO is produced excessively, it can lead to the oxidative damage of biomolecules, resulting in organ damage and various diseases. Therefore, it is imperative to have a straightforward, quick and reliable method for over watching the minimum amount of ClO in different environments. Results: Herein, a new probe TTM, containing thienothiophene and malononitrile units, was developed for exceptionally selective and sensitive hypochlorite (ClO) detection. TTM demonstrated a rapid “turn-on” fluorescence response (<30 s), naked-eye detection (colorimetric), voltammetric read-out with anodic scan, low detection limit (LOD = 0.58 μM and 1.43 μM for optical and electrochemical methods, respectively) and applicability in detecting ClO in real water samples and living cells. Significance and novelty: This study represents one of the rare examples of a small thienothiophene-based molecule for both optical and electrochemical detections of ClO in an aqueous medium.

Orijinal dilİngilizce
Makale numarası125545
DergiTalanta
Hacim270
DOI'lar
Yayın durumuYayınlandı - 1 Nis 2024

Bibliyografik not

Publisher Copyright:
© 2023 Elsevier B.V.

Finansman

The authors gratefully acknowledge TUBITAK UME for financial support, Muhiddin ÇERGEL for NMR analysis. Special thanks to Üçüncü Research Group at İzmir Katip Çelebi University for cell experiment facilities.

FinansörlerFinansör numarası
Ulusal Metroloji Enstitüsü, Türkiye Bilimsel ve Teknolojik Araştirma Kurumu

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