Özet
Background: Hypochlorite/hypochlorous acid (ClO−/HOCl) is a biologically crucial reactive oxygen species (ROS), produced in living organisms and has a critical role as an antimicrobial agent in the natural defense system. However, when ClO− is produced excessively, it can lead to the oxidative damage of biomolecules, resulting in organ damage and various diseases. Therefore, it is imperative to have a straightforward, quick and reliable method for over watching the minimum amount of ClO− in different environments. Results: Herein, a new probe TTM, containing thienothiophene and malononitrile units, was developed for exceptionally selective and sensitive hypochlorite (ClO−) detection. TTM demonstrated a rapid “turn-on” fluorescence response (<30 s), naked-eye detection (colorimetric), voltammetric read-out with anodic scan, low detection limit (LOD = 0.58 μM and 1.43 μM for optical and electrochemical methods, respectively) and applicability in detecting ClO− in real water samples and living cells. Significance and novelty: This study represents one of the rare examples of a small thienothiophene-based molecule for both optical and electrochemical detections of ClO− in an aqueous medium.
Orijinal dil | İngilizce |
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Makale numarası | 125545 |
Dergi | Talanta |
Hacim | 270 |
DOI'lar | |
Yayın durumu | Yayınlandı - 1 Nis 2024 |
Bibliyografik not
Publisher Copyright:© 2023 Elsevier B.V.
Finansman
The authors gratefully acknowledge TUBITAK UME for financial support, Muhiddin ÇERGEL for NMR analysis. Special thanks to Üçüncü Research Group at İzmir Katip Çelebi University for cell experiment facilities.
Finansörler | Finansör numarası |
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Ulusal Metroloji Enstitüsü, Türkiye Bilimsel ve Teknolojik Araştirma Kurumu |