TY - JOUR
T1 - Usage of natural chitosan membrane obtained from insect corneal lenses as a drug carrier and its potential for point of care tests
AU - İlk, Sedef
AU - Ramanauskaitė, Aurelija
AU - Koç Bilican, Behlül
AU - Mulerčikas, Povilas
AU - Çam, Dilek
AU - Onses, M. Serdar
AU - Torun, Ilker
AU - Kazlauskaitė, Sonata
AU - Baublys, Vykintas
AU - Aydın, Ömer
AU - Zang, Lian Sheng
AU - Kaya, Murat
N1 - Publisher Copyright:
© 2018
PY - 2020/7
Y1 - 2020/7
N2 - Chitosan is an indispensable biopolymer for use as a drug carrier thanks to its non-toxic, biodegradable, biocompatible, antimicrobial, and anti-oxidative nature. In previous studies, chitosan was first dissolved into weak acids and formed into gel, then used for carrying pharmaceutically active compounds such as nanoparticles, capsules, composites, and films. Using the produced chitosan gel after dissolving it in weak acids has advantages, such as ease of processing for loading the required amount of active substance and making the desired shape and size. However, dissolved chitosan loses some of its natural properties such as fibrous structure, crystallinity, and thermal stability. In this study, for the first time, three-dimensional chitosan lenses obtained from an insect's (Tabanus bovinus) compound eyes, with the original shape intact, were tested as a drug carrier. A model drug, quercetin, was loaded into chitosan membrane, and its release profile was examined. Also, a point-of-care test was conducted for both chitin and chitosan membranes. Chitin and chitosan membranes obtained from insect corneal lenses were characterized by using FTIR, TGA, elemental analysis, and surface wettability analysis as well as stereo, binocular, and scanning electron microscopies. It was observed that chitosan membrane could be used as a drug carrier material. Both chitin and chitosan membranes will be improved for lateral flow assay, and these membranes can be tested for other bioengineering applications in further studies.
AB - Chitosan is an indispensable biopolymer for use as a drug carrier thanks to its non-toxic, biodegradable, biocompatible, antimicrobial, and anti-oxidative nature. In previous studies, chitosan was first dissolved into weak acids and formed into gel, then used for carrying pharmaceutically active compounds such as nanoparticles, capsules, composites, and films. Using the produced chitosan gel after dissolving it in weak acids has advantages, such as ease of processing for loading the required amount of active substance and making the desired shape and size. However, dissolved chitosan loses some of its natural properties such as fibrous structure, crystallinity, and thermal stability. In this study, for the first time, three-dimensional chitosan lenses obtained from an insect's (Tabanus bovinus) compound eyes, with the original shape intact, were tested as a drug carrier. A model drug, quercetin, was loaded into chitosan membrane, and its release profile was examined. Also, a point-of-care test was conducted for both chitin and chitosan membranes. Chitin and chitosan membranes obtained from insect corneal lenses were characterized by using FTIR, TGA, elemental analysis, and surface wettability analysis as well as stereo, binocular, and scanning electron microscopies. It was observed that chitosan membrane could be used as a drug carrier material. Both chitin and chitosan membranes will be improved for lateral flow assay, and these membranes can be tested for other bioengineering applications in further studies.
KW - Chitin
KW - Chitosan
KW - Drug carrier
KW - Insect eyes
KW - Point of care test
KW - Quercetin
UR - http://www.scopus.com/inward/record.url?scp=85082513710&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2020.110897
DO - 10.1016/j.msec.2020.110897
M3 - Article
C2 - 32409054
AN - SCOPUS:85082513710
SN - 0928-4931
VL - 112
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 110897
ER -