The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis

Demet Goen Colak; Ioan Cianga; Dilek Odaci Demirkol; Ozge Kozgus; E. Ilker Medine; Serhan Sakarya; Perihan Unak; Suna Timur; Yusuf Yagci

doi:10.1039/c2jm30692a

The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis

Demet Goen Colak
, Ioan Cianga
, Dilek Odaci Demirkol
, Ozge Kozgus
, E. Ilker Medine
, Serhan Sakarya
, Perihan Unak
, Suna Timur^*
, Yusuf Yagci

^*Corresponding author for this work

Department of Chemistry

Istanbul Technical University
Petru Poni Institute of Macromolecular Chemistry
Ege University
Adnan Menderes University

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via ¹²⁵I which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.

Original language	English
Pages (from-to)	9293-9300
Number of pages	8
Journal	Journal of Materials Chemistry
Volume	22
Issue number	18
DOIs	https://doi.org/10.1039/c2jm30692a
Publication status	Published - 14 May 2012

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10.1039/c2jm30692a

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title = "The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis",

abstract = "Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via 125I which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.",

author = "Colak, \{Demet Goen\} and Ioan Cianga and Demirkol, \{Dilek Odaci\} and Ozge Kozgus and Medine, \{E. Ilker\} and Serhan Sakarya and Perihan Unak and Suna Timur and Yusuf Yagci",

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doi = "10.1039/c2jm30692a",

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T1 - The synthesis and targeting of PPP-type copolymers to breast cancer cells

T2 - Multifunctional platforms for imaging and diagnosis

AU - Colak, Demet Goen

AU - Cianga, Ioan

AU - Demirkol, Dilek Odaci

AU - Kozgus, Ozge

AU - Medine, E. Ilker

AU - Sakarya, Serhan

AU - Unak, Perihan

AU - Timur, Suna

AU - Yagci, Yusuf

PY - 2012/5/14

Y1 - 2012/5/14

N2 - Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via 125I which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.

AB - Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via 125I which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.

UR - https://www.scopus.com/pages/publications/84859851587

U2 - 10.1039/c2jm30692a

DO - 10.1039/c2jm30692a

M3 - Article

AN - SCOPUS:84859851587

SN - 0959-9428

VL - 22

SP - 9293

EP - 9300

JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

IS - 18

ER -

The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis

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