The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis

Demet Goen Colak; Ioan Cianga; Dilek Odaci Demirkol; Ozge Kozgus; E. Ilker Medine; Serhan Sakarya; Perihan Unak; Suna Timur; Yusuf Yagci

doi:10.1039/c2jm30692a

The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis

Demet Goen Colak, Ioan Cianga, Dilek Odaci Demirkol, Ozge Kozgus, E. Ilker Medine, Serhan Sakarya, Perihan Unak, Suna Timur^*, Yusuf Yagci

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via ¹²⁵I which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.

Original language	English
Pages (from-to)	9293-9300
Number of pages	8
Journal	Journal of Materials Chemistry
Volume	22
Issue number	18
DOIs	https://doi.org/10.1039/c2jm30692a
Publication status	Published - 14 May 2012

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abstract = "Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via 125I which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.",

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T2 - Multifunctional platforms for imaging and diagnosis

AU - Colak, Demet Goen

AU - Cianga, Ioan

AU - Demirkol, Dilek Odaci

AU - Kozgus, Ozge

AU - Medine, E. Ilker

AU - Sakarya, Serhan

AU - Unak, Perihan

AU - Timur, Suna

AU - Yagci, Yusuf

PY - 2012/5/14

Y1 - 2012/5/14

N2 - Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via 125I which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.

AB - Herein, we demonstrate the synthesis and application of water-soluble, biomolecule conjugated PPP copolymers bearing poly(ethylene glycol) (PEG) side chains as fluorescent probes for the in vitro imaging of cancer cells. The targeting of fluorescent polymers to breast cancer cells allows effective visualization and discrimination of MCF7 cells from human mammary epithelial cells. Furthermore, these materials are also suitable for efficient radiolabeling via 125I which enables dual-modality holding the possibility of both radioactive and fluorescence imaging in cancer diagnosis applications.

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JO - Journal of Materials Chemistry

JF - Journal of Materials Chemistry

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ER -

The synthesis and targeting of PPP-type copolymers to breast cancer cells: Multifunctional platforms for imaging and diagnosis

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