TY - GEN
T1 - Temperature dependent optical properties of individual vascular wall components measured by OCT
AU - Van Leeuwen, Ton G.
AU - Van Der Meer, Freek J.
AU - Faber, Dirk J.
AU - Çilesiz, Inci
PY - 2006
Y1 - 2006
N2 - Optical properties of tissues and tissue components are important parameters in biomedical optics. We report measurements of tissue refractive index n, and the attenuation coefficient μt, using optical coherence tomography of individual vascular wall layers and plaque components. Moreover, since the temperature dependence of optical properties is widely known, we compared measurements at room and body temperatures. A decrease of n and μt was observed in all samples, with most profound effect on samples with high lipid content. The sample temperature is of influence on the quantitative measurements within OCT images. For extrapolation of ex vivo experimental results, especially for structures with high lipid content, this effect should be taken into account.
AB - Optical properties of tissues and tissue components are important parameters in biomedical optics. We report measurements of tissue refractive index n, and the attenuation coefficient μt, using optical coherence tomography of individual vascular wall layers and plaque components. Moreover, since the temperature dependence of optical properties is widely known, we compared measurements at room and body temperatures. A decrease of n and μt was observed in all samples, with most profound effect on samples with high lipid content. The sample temperature is of influence on the quantitative measurements within OCT images. For extrapolation of ex vivo experimental results, especially for structures with high lipid content, this effect should be taken into account.
KW - Curve fitting
KW - Functional Measurements
KW - Optical Coherence Tomography
UR - http://www.scopus.com/inward/record.url?scp=33646196869&partnerID=8YFLogxK
U2 - 10.1117/12.650505
DO - 10.1117/12.650505
M3 - Conference contribution
AN - SCOPUS:33646196869
SN - 0819461202
SN - 9780819461209
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
T2 - Photonic Therapeutics and Diagnostics II
Y2 - 21 January 2006 through 24 January 2006
ER -