Abstract
Optical properties of tissues and tissue components are important parameters in biomedical optics. We report measurements of tissue refractive index n and the attenuation coefficient μt using optical coherence tomography (OCT) of individual vascular wall layers and plaque components. Moreover, since the temperature dependence of optical properties is widely known, we compare measurements at room and body temperatures. A decrease of n and μt is observed in all samples, with the most profound effect on samples with high lipid content. The sample temperature is of influence on the quantitative measurements within OCT images. For extrapolation of ex-vivo experimental results, especially for structures with high lipid content, this effect should be taken into account.
| Original language | English |
|---|---|
| Article number | 041120 |
| Journal | Journal of Biomedical Optics |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2006 |
Funding
The authors wish to thank G. Pasterkamp and the Utrecht Athero-Express biobank for the donation of atherosclerotic samples. This research is sponsored by the Netherlands Heart Foundation (grant 99.199) and is also part of the research program of the “Stichting voor Fundamenteel Onderzoek der Materie (FOM),” which is financially supported by the Ned-erlandse Organisatie voor Wetenschappelijk Onderzoek (NWO). We acknowledge the Interuniversity Cardiology Institute of the Netherlands (ICIN) for financial support.
| Funders | Funder number |
|---|---|
| Netherlands Heart Foundation | 99.199 |
| Stichting voor Fundamenteel Onderzoek der Materie | |
| Nederlandse Organisatie voor Wetenschappelijk Onderzoek | |
| Foundation for Fundamental Research on Matter |
Keywords
- Optical coherence tomography
- Temperature dependence
- Vascular wall