Targeting mitochondrial quality control in muscle aging: Natural dietary products as potential interventions

Qi Chen, Weisu Huang, Esra Capanoglu, Amel Thanina Amrouche, Baiyi Lu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Mitochondria are the main sources of energy production for muscle tissues, including skeletal, cardiac, or smooth muscle, to support their activities. Mitochondrial dysfunction and dysregulation of their quality control systems are significant characteristics in aged muscle. Increasing evidence indicates that natural products, especially phytochemicals, can prevent or improve age-related muscle disorders. Among them, some dietary components specifically regulate mitochondrial quality control (MQC) to play their efficacy. However, the content of related studies is currently not systematically reviewed. In this review, composition, changes, and associated regulators in the MQC network during muscle aging were summarized by comprehensive literature retrieval. Subsequently, the effects and mechanisms of dietary active ingredients on this control network were described. This review showed that mitochondrial dysfunction is a common feature in different types of muscle aging. And four main ways of MQC are involved in maintaining mitochondrial homeostasis and they form a tight and integral system, for muscle-healthy aging. The benefits of specific endogenous metabolites and exogenous components on aged muscle health are mediated in the above ways. Dietary phytochemicals including phenols, terpenoids, and alkaloids, unfold their influential roles in delaying muscle aging via promoting mitochondrial biogenesis and mitophagy. These findings suggest that MQC is a promising action site against muscle aging and food or herbal-derived natural products are representative potential interventions. More clinical studies in the future are worthy of future investigation of these natural products.

Original languageEnglish
Pages (from-to)1206-1241
Number of pages36
JournalFood Frontiers
Volume4
Issue number3
DOIs
Publication statusPublished - Sept 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Food Frontiers published by John Wiley & Sons Australia, Ltd and Nanchang University, Northwest University, Jiangsu University, Zhejiang University, Fujian Agriculture and Forestry University.

Funding

This work was supported by the Zhejiang Provincial Basic Public Welfare Research under Grant LGN20C200010; the Fundamental Research Funds for the Provincial Universities, Zhejiang Institute of Economics and Trade under Grant 19SBYB07; the Zhejiang Provincial Major R & D Program under Grant 2019C02070. This work was supported by the Zhejiang Provincial Basic Public Welfare Research under Grant LGN20C200010; the Fundamental Research Funds for the Provincial Universities, Zhejiang Institute of Economics and Trade under Grant 19SBYB07; the Zhejiang Provincial Major R & D Program under Grant 2019C02070.

FundersFunder number
Fundamental Research Funds for the Provincial Universities
Zhejiang Institute of Economics and Trade19SBYB07
Zhejiang Provincial Major R & D Program2019C02070
Fundamental Research Funds for the Provincial Universities of Zhejiang
Basic Public Welfare Research Program of Zhejiang ProvinceLGN20C200010

    Keywords

    • antiaging
    • mitochondria
    • phytochemicals
    • quality control
    • regulators
    • sarcopenia

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