TY - JOUR
T1 - Synthesis, structural characterization and electrochemical evaluation of schiff base transition metal complexes with ceftazidime
AU - Tarinc, Derya
AU - Muslu, Harun
AU - Cesme, Mustafa
AU - Gölcü, Ayegül
AU - Tumer, Mehmet
AU - Ozkan, Sibel A.
PY - 2013
Y1 - 2013
N2 - In this study, transition metals (Cu(II), Co(II), Ni(II), Fe(III) and Ru(III)), complexes of Schiff base derived from (6R,7R,Z)-7-(2-(2-aminothiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetamido)-8-oxo-3-(pyridinium- ylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate, Ceftazidime; CFZ) and p-dimethyl amino benzaldehyde (DAB) were prepared and characterized by the analytical and spectroscopic methods. The analytical data show the composition of the metal complex to be [M(CFZ-DAB)Cln]Cl, where CFZ-DAB is the Schiff base ligand and n=1 for Cu(II), Co(II), Ni(II) and n=2 for Fe(III) and Ru(III) complexes. The conductance data indicate that all the complexes are strong-electrolytes. The compound (CFZ-DAB) behaves as a tridentate ligand. But, obtained complexes have mononuclear nature. The electrochemical properties of the metal complexes were investigated by cyclic voltammetry (CV) using glassy carbon electrode. The oxidation/reduction of metal complexes was irreversible/reversible and exhibited diffusion controlled process depending on pH. The dependence of intensities of currents and potentials on pH, concentration, scan rate, nature of the buffer was investigated. The oxidation/reduction mechanism was proposed and discussed.
AB - In this study, transition metals (Cu(II), Co(II), Ni(II), Fe(III) and Ru(III)), complexes of Schiff base derived from (6R,7R,Z)-7-(2-(2-aminothiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetamido)-8-oxo-3-(pyridinium- ylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate, Ceftazidime; CFZ) and p-dimethyl amino benzaldehyde (DAB) were prepared and characterized by the analytical and spectroscopic methods. The analytical data show the composition of the metal complex to be [M(CFZ-DAB)Cln]Cl, where CFZ-DAB is the Schiff base ligand and n=1 for Cu(II), Co(II), Ni(II) and n=2 for Fe(III) and Ru(III) complexes. The conductance data indicate that all the complexes are strong-electrolytes. The compound (CFZ-DAB) behaves as a tridentate ligand. But, obtained complexes have mononuclear nature. The electrochemical properties of the metal complexes were investigated by cyclic voltammetry (CV) using glassy carbon electrode. The oxidation/reduction of metal complexes was irreversible/reversible and exhibited diffusion controlled process depending on pH. The dependence of intensities of currents and potentials on pH, concentration, scan rate, nature of the buffer was investigated. The oxidation/reduction mechanism was proposed and discussed.
KW - Ceftazidime
KW - Cyclic voltammetry
KW - Schiff base complexes
UR - http://www.scopus.com/inward/record.url?scp=84875327174&partnerID=8YFLogxK
U2 - 10.2174/157341113805218965
DO - 10.2174/157341113805218965
M3 - Article
AN - SCOPUS:84875327174
SN - 1573-4110
VL - 9
SP - 319
EP - 332
JO - Current Analytical Chemistry
JF - Current Analytical Chemistry
IS - 2
ER -