Synthesis of quaternized zinc(II) and cobalt(II) phthalocyanines bearing pyridine-2-yl-ethynyl groups and their DNA binding properties

Maryam Moeini Alishah, H. Yasemin Yenilmez, Özçeşmeci Ibrahim, Sesalan Behice Şebnem, Zehra Altuntaş Bayır

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15 Citations (Scopus)

Abstract

The synthesis and biological properties of tetra-substituted zinc and cobalt phthalocyanines bearing ethynylpyridine units on the periphery and their quaternized derivatives have been reported. The binding of quaternized ZnPc and CoPc (Q-ZnPc and Q-CoPc) with calf thymus DNA was investigated by UV-Vis spectrophotometric methods and thermodynamics. The mixtures of Q-ZnPc or Q-CoPc and DNA solutions were used to determine the change in the thermal melting temperature of DNA with the thermal denaturation profile. Thermodynamic parameters that show the spontaneity of the reactions between DNA and the quaternized phthalocyanines were investigated. Kb binding constants at a degree of 105 and 106 for Q-ZnPc and Q-CoPc, respectively, showed that the phthalocyanines bound to DNA fragments efficiently and thermodynamic data proved that the binding process was spontaneous and entropy-driven. The interactions between Q-ZnPc and Q-CoPc and DNA in an aqueous environment corresponded to electrostatic attractions and nonspecific binding.

Original languageEnglish
Pages (from-to)572-585
Number of pages14
JournalTurkish Journal of Chemistry
Volume42
Issue number2
DOIs
Publication statusPublished - 1 Jan 2018

Bibliographical note

Publisher Copyright:
© TÜBITAK.

Funding

This work was supported by the research funds of Istanbul Technical University.

FundersFunder number
Istanbul Teknik Üniversitesi

    Keywords

    • Calf thymus DNA
    • Cross-coupling
    • Entropy
    • Phthalocyanine
    • Pyridine

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