Synthesis of novel tetracationic phthalocyanines and investigation of their DNA-binding properties

Didem Evren, Ayfer Kalkan Burat*, Ibrahim Özçeşmeci, B. Şebnem Sesalan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


The synthesis of novel, tetracationic zinc (1Q) and metal-free (2Q) phthalocyanines (Pcs) bearing 4-((7-(trifluoromethyl)quinolin-4-yl)oxy) units on the periphery have been reported. The new compounds were characterized by using elemental analysis, 1H NMR, UV-vis and FT-IR spectroscopy and mass spectrometry. The binding properties of both 1Q and 2Q to CT-DNA are investigated in water by absorption and fluorescence spectroscopy. The quenching effect of all quaternized phthalocyanines (1Q and 2Q) on the fluorescence intensity of 4′,6-diamidino-2-phenylindoledihydrochloride (DAPI Gold)-DNA complex was determined. This study showed that the water-soluble quaternized zinc (1Q) and metal-free phthalocyanines (2Q) exhibit efficient DNA-binding activity.

Original languageEnglish
Pages (from-to)475-482
Number of pages8
JournalDyes and Pigments
Issue number2
Publication statusPublished - Feb 2013


This work was supported by TUBITAK (Project no: 110T800 ).

FundersFunder number


    • Aggregation
    • DNA
    • Photodynamic therapy
    • Phthalocyanines
    • Quaternized
    • Water soluble


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