TY - JOUR
T1 - Synthesis of Bovine Serum Albumin-Coated Magnetic Single-Walled Carbon Nanotubes as a Delivery System for Mitoxantrone
AU - Aydın, Buğçe
AU - Bozoğlu, Serdar
AU - Karatepe, Nilgün
AU - Güner, F. Seniha
N1 - Publisher Copyright:
© 2025 The Authors. Published by American Chemical Society.
PY - 2025/1/14
Y1 - 2025/1/14
N2 - In this study, a bovine serum albumin (BSA)-coated magnetic single-walled carbon nanotube (mCNT) was synthesized using covalent functionalization. Mitoxantrone (MTO) was chosen as a model drug, and loading/release profiles of mCNTs were evaluated. To synthesize BSA-coated mCNT, 1-ethyl-3-(3-(dimethylamino)propyl) carbodiimide and N-hydroxysuccinimide were used as cross-linking agents. The success of the functionalization process was demonstrated through various analysis techniques such as Fourier transform infrared spectroscopy, Raman spectroscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy, vibrating sample magnetometer, and scanning electron microscopy. The saturation magnetization of mCNT-BSA was 15.6 emu/g, indicating its potential for magnetically targeted drug delivery systems. Finally, MTO was physically loaded on the BSA-coated mCNT (mCNT-BSA) and the results were compared to those of mCNT. mCNT-BSA showed less drug loading capacity but more release response than mCNT. Considering drug release and cytotoxicity test results, MTO-loaded mCNT-BSA nanoparticles have great potential for cancer treatment.
AB - In this study, a bovine serum albumin (BSA)-coated magnetic single-walled carbon nanotube (mCNT) was synthesized using covalent functionalization. Mitoxantrone (MTO) was chosen as a model drug, and loading/release profiles of mCNTs were evaluated. To synthesize BSA-coated mCNT, 1-ethyl-3-(3-(dimethylamino)propyl) carbodiimide and N-hydroxysuccinimide were used as cross-linking agents. The success of the functionalization process was demonstrated through various analysis techniques such as Fourier transform infrared spectroscopy, Raman spectroscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy, vibrating sample magnetometer, and scanning electron microscopy. The saturation magnetization of mCNT-BSA was 15.6 emu/g, indicating its potential for magnetically targeted drug delivery systems. Finally, MTO was physically loaded on the BSA-coated mCNT (mCNT-BSA) and the results were compared to those of mCNT. mCNT-BSA showed less drug loading capacity but more release response than mCNT. Considering drug release and cytotoxicity test results, MTO-loaded mCNT-BSA nanoparticles have great potential for cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=85214994777&partnerID=8YFLogxK
U2 - 10.1021/acsomega.3c09608
DO - 10.1021/acsomega.3c09608
M3 - Article
AN - SCOPUS:85214994777
SN - 2470-1343
VL - 10
SP - 102
EP - 113
JO - ACS Omega
JF - ACS Omega
IS - 1
ER -
