Synthesis of acyclovir metal complexes: Spectral, electrochemical, thermal, and DNA binding studies

M. Vahdettin Avcioglu; Aysegul Golcu

doi:10.1080/15533174.2013.831877

Synthesis of acyclovir metal complexes: Spectral, electrochemical, thermal, and DNA binding studies

M. Vahdettin Avcioglu, Aysegul Golcu^*

^*Corresponding author for this work

Kahramanmaras Sutcu Imam University

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Mononuclear Cu(II), Zn(II), Pt(II), Fe(III), and Ru(III) complexes of acyclovir have been synthesized and characterized using analytical and spectral techniques, involving UV-Vis, FT-IR, mass, and ¹H-NMR. Electrochemical, magnetic, and thermal behavior of complexes have also been investigated. The biological activity of the complexes has been evaluated by examining their ability to bind to calf-thymus DNA (CT DNA) with UV spectroscopy. UV studies of the interaction of the complexes with DNA have shown that these compounds can bind to CT DNA. The binding constants of the acyclovir and its complexes with CT DNA have also been calculated. The synthesized complexes have been tested for their antimicrobial activity using the agar-disc diffusion method in terms of minimum inhibitory concentration. The cytotoxicity activities of complexes have been investigated against the BHV-1 (bovine herpes virus type-1).

Original language	English
Pages (from-to)	581-590
Number of pages	10
Journal	Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry
Volume	45
Issue number	4
DOIs	https://doi.org/10.1080/15533174.2013.831877
Publication status	Published - 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © Taylor & Francis Group, LLC.

Funding

The authors wish to thank TUBITAK (Project No: 109T020 under the COST D39 action), KSU (Project No: 2010/5–16) for the financial supports and Prof. Dr. Metin Dıgrak (Department of Biology, Faculty of Science and Letters, University of Kahramanmaras Sutcu Imam, Campuse of Avsar 46100, Kahramanmaras, Turkey) for antimicrobial studies and Prof. Dr. Taner Karaoglu (Department of Virology, Faculty of Veterinary, Ankara University, 06110 Ankara, Turkey) for antiviral and cytotoxicity studies and Mustafa Cesme (PhD), Harun Muslu (PhD), and Derya Tarınc (PhD) for their technical assistance.

Funders	Funder number
TUBITAK	109T020
Ankara Universitesi
Kansas State University	2010/5–16

Keywords

Acyclovir
Metal-based drugs

Access to Document

10.1080/15533174.2013.831877

Cite this

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title = "Synthesis of acyclovir metal complexes: Spectral, electrochemical, thermal, and DNA binding studies",

abstract = "Mononuclear Cu(II), Zn(II), Pt(II), Fe(III), and Ru(III) complexes of acyclovir have been synthesized and characterized using analytical and spectral techniques, involving UV-Vis, FT-IR, mass, and 1H-NMR. Electrochemical, magnetic, and thermal behavior of complexes have also been investigated. The biological activity of the complexes has been evaluated by examining their ability to bind to calf-thymus DNA (CT DNA) with UV spectroscopy. UV studies of the interaction of the complexes with DNA have shown that these compounds can bind to CT DNA. The binding constants of the acyclovir and its complexes with CT DNA have also been calculated. The synthesized complexes have been tested for their antimicrobial activity using the agar-disc diffusion method in terms of minimum inhibitory concentration. The cytotoxicity activities of complexes have been investigated against the BHV-1 (bovine herpes virus type-1).",

keywords = "Acyclovir, Metal-based drugs",

author = "Avcioglu, \{M. Vahdettin\} and Aysegul Golcu",

note = "Publisher Copyright: Copyright {\textcopyright} Taylor \& Francis Group, LLC.",

year = "2015",

doi = "10.1080/15533174.2013.831877",

language = "English",

volume = "45",

pages = "581--590",

journal = "Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry",

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TY - JOUR

T1 - Synthesis of acyclovir metal complexes

T2 - Spectral, electrochemical, thermal, and DNA binding studies

AU - Avcioglu, M. Vahdettin

AU - Golcu, Aysegul

PY - 2015

Y1 - 2015

N2 - Mononuclear Cu(II), Zn(II), Pt(II), Fe(III), and Ru(III) complexes of acyclovir have been synthesized and characterized using analytical and spectral techniques, involving UV-Vis, FT-IR, mass, and 1H-NMR. Electrochemical, magnetic, and thermal behavior of complexes have also been investigated. The biological activity of the complexes has been evaluated by examining their ability to bind to calf-thymus DNA (CT DNA) with UV spectroscopy. UV studies of the interaction of the complexes with DNA have shown that these compounds can bind to CT DNA. The binding constants of the acyclovir and its complexes with CT DNA have also been calculated. The synthesized complexes have been tested for their antimicrobial activity using the agar-disc diffusion method in terms of minimum inhibitory concentration. The cytotoxicity activities of complexes have been investigated against the BHV-1 (bovine herpes virus type-1).

AB - Mononuclear Cu(II), Zn(II), Pt(II), Fe(III), and Ru(III) complexes of acyclovir have been synthesized and characterized using analytical and spectral techniques, involving UV-Vis, FT-IR, mass, and 1H-NMR. Electrochemical, magnetic, and thermal behavior of complexes have also been investigated. The biological activity of the complexes has been evaluated by examining their ability to bind to calf-thymus DNA (CT DNA) with UV spectroscopy. UV studies of the interaction of the complexes with DNA have shown that these compounds can bind to CT DNA. The binding constants of the acyclovir and its complexes with CT DNA have also been calculated. The synthesized complexes have been tested for their antimicrobial activity using the agar-disc diffusion method in terms of minimum inhibitory concentration. The cytotoxicity activities of complexes have been investigated against the BHV-1 (bovine herpes virus type-1).

KW - Acyclovir

KW - Metal-based drugs

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U2 - 10.1080/15533174.2013.831877

DO - 10.1080/15533174.2013.831877

M3 - Article

AN - SCOPUS:84908405894

SN - 1553-3174

VL - 45

SP - 581

EP - 590

JO - Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry

JF - Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry

IS - 4

ER -

Synthesis of acyclovir metal complexes: Spectral, electrochemical, thermal, and DNA binding studies

Abstract

Bibliographical note

Funding

Keywords

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