Synthesis of acyclovir metal complexes: Spectral, electrochemical, thermal, and DNA binding studies

M. Vahdettin Avcioglu, Aysegul Golcu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Mononuclear Cu(II), Zn(II), Pt(II), Fe(III), and Ru(III) complexes of acyclovir have been synthesized and characterized using analytical and spectral techniques, involving UV-Vis, FT-IR, mass, and 1H-NMR. Electrochemical, magnetic, and thermal behavior of complexes have also been investigated. The biological activity of the complexes has been evaluated by examining their ability to bind to calf-thymus DNA (CT DNA) with UV spectroscopy. UV studies of the interaction of the complexes with DNA have shown that these compounds can bind to CT DNA. The binding constants of the acyclovir and its complexes with CT DNA have also been calculated. The synthesized complexes have been tested for their antimicrobial activity using the agar-disc diffusion method in terms of minimum inhibitory concentration. The cytotoxicity activities of complexes have been investigated against the BHV-1 (bovine herpes virus type-1).

Original languageEnglish
Pages (from-to)581-590
Number of pages10
JournalSynthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry
Volume45
Issue number4
DOIs
Publication statusPublished - 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © Taylor & Francis Group, LLC.

Funding

The authors wish to thank TUBITAK (Project No: 109T020 under the COST D39 action), KSU (Project No: 2010/5–16) for the financial supports and Prof. Dr. Metin Dıgrak (Department of Biology, Faculty of Science and Letters, University of Kahramanmaras Sutcu Imam, Campuse of Avsar 46100, Kahramanmaras, Turkey) for antimicrobial studies and Prof. Dr. Taner Karaoglu (Department of Virology, Faculty of Veterinary, Ankara University, 06110 Ankara, Turkey) for antiviral and cytotoxicity studies and Mustafa Cesme (PhD), Harun Muslu (PhD), and Derya Tarınc (PhD) for their technical assistance.

FundersFunder number
TUBITAK109T020
Ankara Universitesi
Kansas State University2010/5–16

    Keywords

    • Acyclovir
    • Metal-based drugs

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