Synthesis of 2-oxazolines via boron esters of N-(2-hydroxyethyl) amides

Baris Ilkgul; Deniz Gunes; Okan Sirkecioglu; Niyazi Bicak

doi:10.1016/j.tetlet.2010.07.167

Synthesis of 2-oxazolines via boron esters of N-(2-hydroxyethyl) amides

Baris Ilkgul, Deniz Gunes, Okan Sirkecioglu^*, Niyazi Bicak

^*Corresponding author for this work

Istanbul Technical University

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

A new, convenient, one-pot process is presented for the synthesis of 2-oxazolines in high yields (75-94%) via boron esters of N-(2-hydroxyethyl) amides. The procedure involves thermolysis of the boron esters at 240-260 °C, in the presence of solid CaO as an acid scavenger and allows the preparation of oxazolines from hydroxyethyl amides of aliphatic and aromatic monocarboxylic acids.

Original language	English
Pages (from-to)	5313-5315
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	40
DOIs	https://doi.org/10.1016/j.tetlet.2010.07.167
Publication status	Published - 6 Oct 2010

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10.1016/j.tetlet.2010.07.167

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abstract = "A new, convenient, one-pot process is presented for the synthesis of 2-oxazolines in high yields (75-94\%) via boron esters of N-(2-hydroxyethyl) amides. The procedure involves thermolysis of the boron esters at 240-260 °C, in the presence of solid CaO as an acid scavenger and allows the preparation of oxazolines from hydroxyethyl amides of aliphatic and aromatic monocarboxylic acids.",

author = "Baris Ilkgul and Deniz Gunes and Okan Sirkecioglu and Niyazi Bicak",

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T1 - Synthesis of 2-oxazolines via boron esters of N-(2-hydroxyethyl) amides

AU - Ilkgul, Baris

AU - Gunes, Deniz

AU - Sirkecioglu, Okan

AU - Bicak, Niyazi

PY - 2010/10/6

Y1 - 2010/10/6

N2 - A new, convenient, one-pot process is presented for the synthesis of 2-oxazolines in high yields (75-94%) via boron esters of N-(2-hydroxyethyl) amides. The procedure involves thermolysis of the boron esters at 240-260 °C, in the presence of solid CaO as an acid scavenger and allows the preparation of oxazolines from hydroxyethyl amides of aliphatic and aromatic monocarboxylic acids.

AB - A new, convenient, one-pot process is presented for the synthesis of 2-oxazolines in high yields (75-94%) via boron esters of N-(2-hydroxyethyl) amides. The procedure involves thermolysis of the boron esters at 240-260 °C, in the presence of solid CaO as an acid scavenger and allows the preparation of oxazolines from hydroxyethyl amides of aliphatic and aromatic monocarboxylic acids.

UR - https://www.scopus.com/pages/publications/77956344065

U2 - 10.1016/j.tetlet.2010.07.167

DO - 10.1016/j.tetlet.2010.07.167

M3 - Article

AN - SCOPUS:77956344065

SN - 0040-4039

VL - 51

SP - 5313

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 40

ER -

Synthesis of 2-oxazolines via boron esters of N-(2-hydroxyethyl) amides

Abstract

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