Synthesis of 2-oxazolines via boron esters of N-(2-hydroxyethyl) amides

Baris Ilkgul, Deniz Gunes, Okan Sirkecioglu*, Niyazi Bicak

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

A new, convenient, one-pot process is presented for the synthesis of 2-oxazolines in high yields (75-94%) via boron esters of N-(2-hydroxyethyl) amides. The procedure involves thermolysis of the boron esters at 240-260 °C, in the presence of solid CaO as an acid scavenger and allows the preparation of oxazolines from hydroxyethyl amides of aliphatic and aromatic monocarboxylic acids.

Original languageEnglish
Pages (from-to)5313-5315
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number40
DOIs
Publication statusPublished - 6 Oct 2010

Fingerprint

Dive into the research topics of 'Synthesis of 2-oxazolines via boron esters of N-(2-hydroxyethyl) amides'. Together they form a unique fingerprint.

Cite this