Synthesis, crystal structures, DNA binding and cytotoxicity of two novel platinum(II) complexes containing 2-(hydroxymethyl)pyridine and pyridine-2-carboxylate ligands

Ceyda Icsel, Veysel T. Yilmaz*, Aysegul Golcu, Engin Ulukaya, Orhan Buyukgungor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Two new platinum(II) complexes, trans-[Pt(2-mpy)2] ·4H2O (1) and [PtCl(2-pyc)(2-hmpy)]·H2O (2), where 2-hmpy = 2-(hydroxymethyl)pyridine, 2-mpy = deprotonated 2-hmpy and 2-pyc = pyridine-2-carboxylate, have been synthesized and characterized by elemental analysis, IR, NMR, and X-ray crystallography. The DNA binding affinities of these complexes for Fish Sperm DNA (FS-DNA) were investigated using fluorescence, viscosity, thermal denaturation and gel electrophoresis measurements. Fluorescence analysis indicates that complex 1 binds to DNA by a single intercalative mechanism, while complex 2 exhibits two types of interactions such as intercalation and covalent binding. Gel electrophoresis assay demonstrates ability of the complexes to cleavage the supercoiled pBR322 plasmid DNA. The in vitro cytotoxicities of both complexes were preliminarily evaluated and the cytotoxicity of complex 1 against the human lung cancer cells (H1299) is similar to oxaliplatin, but higher than transplatin and carboplatin.

Original languageEnglish
Pages (from-to)2117-2122
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number7
DOIs
Publication statusPublished - 1 Apr 2013
Externally publishedYes

Funding

We thank Uludag University for the financial support given to the project.

FundersFunder number
Uludag University

    Keywords

    • 2-(Hydroxymethyl)pyridine
    • Cytotoxic activity
    • DNA binding
    • Pt(II) complexes
    • Pyridine-2-carboxylate

    Fingerprint

    Dive into the research topics of 'Synthesis, crystal structures, DNA binding and cytotoxicity of two novel platinum(II) complexes containing 2-(hydroxymethyl)pyridine and pyridine-2-carboxylate ligands'. Together they form a unique fingerprint.

    Cite this