Synthesis and in vitro study of new highly boronated phthalocyanine

Akim V. Shmal'Ko, Anastasija V. Efremenko, Anastasija A. Ignatova, Igor B. Sivaev*, Alexey V. Feofanov, Esin Hamuryudan, Ahmet Gül, Leonid V. Kovalenko, Shicheng Qi, Vladimir I. Bregadze

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A new highly boronated Zn(II)-phthalocyanine with eight cobalt bis(dicarbollide) units (144 boron atoms) was prepared and its intracellular accumulation and distribution in GL6 human glioblastoma cells were studied. It was found that the boronated phthalocyanine undergoes strong aggregation in intracellular environment.

Original languageEnglish
Pages (from-to)960-966
Number of pages7
JournalJournal of Porphyrins and Phthalocyanines
Volume18
Issue number10-11
DOIs
Publication statusPublished - 19 May 2014

Bibliographical note

Publisher Copyright:
Copyright © 2014 World Scientific Publishing Company.

Funding

closo-dodecaborate for cobalt bis(dicarbollide) should result in enlarged intracellular boron accumulation that would be sufficient for the BNCT requirements. This suggestion is supported by the results of in vitro study of boronated chlorin e6 derivatives demonstrating higher cell uptake of cobalt bis(dicarbollide) containing porphyrins vs. closo-dodecaborate containing ones [27, 28].

FundersFunder number
Russian Foundation for Basic Research13-03-00581, 12-03-91375
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu211T052

    Keywords

    • cobalt bis(dicarbollide)
    • intracellular accumulation
    • intracellular distribution
    • phthalocyanine
    • synthesis

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