Synthesis and in vitro study of new highly boronated phthalocyanine

Akim V. Shmal'Ko; Anastasija V. Efremenko; Anastasija A. Ignatova; Igor B. Sivaev; Alexey V. Feofanov; Esin Hamuryudan; Ahmet Gül; Leonid V. Kovalenko; Shicheng Qi; Vladimir I. Bregadze

doi:10.1142/S1088424614500746

Synthesis and in vitro study of new highly boronated phthalocyanine

Akim V. Shmal'Ko, Anastasija V. Efremenko, Anastasija A. Ignatova, Igor B. Sivaev^*, Alexey V. Feofanov, Esin Hamuryudan, Ahmet Gül, Leonid V. Kovalenko, Shicheng Qi, Vladimir I. Bregadze

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A new highly boronated Zn(II)-phthalocyanine with eight cobalt bis(dicarbollide) units (144 boron atoms) was prepared and its intracellular accumulation and distribution in GL6 human glioblastoma cells were studied. It was found that the boronated phthalocyanine undergoes strong aggregation in intracellular environment.

Original language	English
Pages (from-to)	960-966
Number of pages	7
Journal	Journal of Porphyrins and Phthalocyanines
Volume	18
Issue number	10-11
DOIs	https://doi.org/10.1142/S1088424614500746
Publication status	Published - 19 May 2014

Bibliographical note

Publisher Copyright:
Copyright © 2014 World Scientific Publishing Company.

Funding

closo-dodecaborate for cobalt bis(dicarbollide) should result in enlarged intracellular boron accumulation that would be sufficient for the BNCT requirements. This suggestion is supported by the results of in vitro study of boronated chlorin e6 derivatives demonstrating higher cell uptake of cobalt bis(dicarbollide) containing porphyrins vs. closo-dodecaborate containing ones [27, 28].

Funders	Funder number
Russian Foundation for Basic Research	13-03-00581, 12-03-91375
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu	211T052

Keywords

cobalt bis(dicarbollide)
intracellular accumulation
intracellular distribution
phthalocyanine
synthesis

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title = "Synthesis and in vitro study of new highly boronated phthalocyanine",

abstract = "A new highly boronated Zn(II)-phthalocyanine with eight cobalt bis(dicarbollide) units (144 boron atoms) was prepared and its intracellular accumulation and distribution in GL6 human glioblastoma cells were studied. It was found that the boronated phthalocyanine undergoes strong aggregation in intracellular environment.",

keywords = "cobalt bis(dicarbollide), intracellular accumulation, intracellular distribution, phthalocyanine, synthesis",

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day = "19",

doi = "10.1142/S1088424614500746",

language = "English",

volume = "18",

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T1 - Synthesis and in vitro study of new highly boronated phthalocyanine

AU - Shmal'Ko, Akim V.

AU - Efremenko, Anastasija V.

AU - Ignatova, Anastasija A.

AU - Sivaev, Igor B.

AU - Feofanov, Alexey V.

AU - Hamuryudan, Esin

AU - Gül, Ahmet

AU - Kovalenko, Leonid V.

AU - Qi, Shicheng

AU - Bregadze, Vladimir I.

PY - 2014/5/19

Y1 - 2014/5/19

N2 - A new highly boronated Zn(II)-phthalocyanine with eight cobalt bis(dicarbollide) units (144 boron atoms) was prepared and its intracellular accumulation and distribution in GL6 human glioblastoma cells were studied. It was found that the boronated phthalocyanine undergoes strong aggregation in intracellular environment.

AB - A new highly boronated Zn(II)-phthalocyanine with eight cobalt bis(dicarbollide) units (144 boron atoms) was prepared and its intracellular accumulation and distribution in GL6 human glioblastoma cells were studied. It was found that the boronated phthalocyanine undergoes strong aggregation in intracellular environment.

KW - cobalt bis(dicarbollide)

KW - intracellular accumulation

KW - intracellular distribution

KW - phthalocyanine

KW - synthesis

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U2 - 10.1142/S1088424614500746

DO - 10.1142/S1088424614500746

M3 - Article

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SN - 1088-4246

VL - 18

SP - 960

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JO - Journal of Porphyrins and Phthalocyanines

JF - Journal of Porphyrins and Phthalocyanines

IS - 10-11

ER -

Synthesis and in vitro study of new highly boronated phthalocyanine

Abstract

Bibliographical note

Funding

Keywords

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