TY - JOUR
T1 - Synthesis and characterization of metal complexes of acebutolol, atenolol, and propranolol antihypertension drugs
AU - Gölcü, Ayşegül
AU - Yücesoy, Cem
AU - Serin, Selahattin
PY - 2004/8
Y1 - 2004/8
N2 - The complexation of two transition metal ions with the β-blocker drugs acebutolol (HL1), atenolol (HL2), and propranolol (HL3) was studied in methanol and acetonitrile media at M:L (metal:ligand) molar ratio from 1:1 to 1:10. Cu(II) complexes with ligands having the stoichiometric ratio 1:4 (mononuclear copper(II) complexes) and 1:1 (binuclear copper(II) complexes) were prepared. The analytical data show that the metal to ligand ratio in the mononuclear Co(II) complexes was 1:2. The complexes were characterized on the basis of analytical data, magnetic moments, atomic absorption, infrared and electronic spectral data. Molar conductivities of the complexes at room temperature were measured. The conductivity values of the mononuclear Cu(II) complexes indicate weak electrolyte behavior, whereas the binuclear Cu(II) and mononuclear Co(II) complexes are non-electrolytes. The thermal properties of all complexes have been studied by the DTA and TG.
AB - The complexation of two transition metal ions with the β-blocker drugs acebutolol (HL1), atenolol (HL2), and propranolol (HL3) was studied in methanol and acetonitrile media at M:L (metal:ligand) molar ratio from 1:1 to 1:10. Cu(II) complexes with ligands having the stoichiometric ratio 1:4 (mononuclear copper(II) complexes) and 1:1 (binuclear copper(II) complexes) were prepared. The analytical data show that the metal to ligand ratio in the mononuclear Co(II) complexes was 1:2. The complexes were characterized on the basis of analytical data, magnetic moments, atomic absorption, infrared and electronic spectral data. Molar conductivities of the complexes at room temperature were measured. The conductivity values of the mononuclear Cu(II) complexes indicate weak electrolyte behavior, whereas the binuclear Cu(II) and mononuclear Co(II) complexes are non-electrolytes. The thermal properties of all complexes have been studied by the DTA and TG.
KW - Metal complexes
KW - Molar conductivity
KW - Transition metal ion
UR - http://www.scopus.com/inward/record.url?scp=3242680396&partnerID=8YFLogxK
U2 - 10.1081/SIM-120039270
DO - 10.1081/SIM-120039270
M3 - Article
AN - SCOPUS:3242680396
SN - 0094-5714
VL - 34
SP - 1259
EP - 1275
JO - Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry
JF - Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry
IS - 7
ER -