Synthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicin

Cagatay Altinkok; Gokhan Acik; Huseyin Riza Ferhat Karabulut; Mustafa Ciftci; Mehmet Atilla Tasdelen; Aydan Dag

doi:10.1002/pat.5478

Synthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicin

Cagatay Altinkok^*, Gokhan Acik^*, Huseyin Riza Ferhat Karabulut, Mustafa Ciftci, Mehmet Atilla Tasdelen, Aydan Dag

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.

Original language	English
Pages (from-to)	4860-4868
Number of pages	9
Journal	Polymers for Advanced Technologies
Volume	32
Issue number	12
DOIs	https://doi.org/10.1002/pat.5478
Publication status	Published - Dec 2021

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Publisher Copyright:
© 2021 John Wiley & Sons Ltd.

Keywords

amphiphilic
drug release
lithocholic acid
photopolymerization

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/pat.5478

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title = "Synthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicin",

abstract = "In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.",

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author = "Cagatay Altinkok and Gokhan Acik and Karabulut, {Huseyin Riza Ferhat} and Mustafa Ciftci and Tasdelen, {Mehmet Atilla} and Aydan Dag",

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AU - Altinkok, Cagatay

AU - Acik, Gokhan

AU - Karabulut, Huseyin Riza Ferhat

AU - Ciftci, Mustafa

AU - Tasdelen, Mehmet Atilla

AU - Dag, Aydan

PY - 2021/12

Y1 - 2021/12

N2 - In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.

AB - In the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.

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KW - photopolymerization

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ER -

Synthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicin

Abstract

Bibliographical note

Keywords

UN SDGs

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