Synthesis and characterization of a novel alkoxy substituted gold(III) phthalocyanine

Cemre Bilal; Altuǧ Mert Sevim; Ahmet Gül

doi:10.1016/j.inoche.2016.04.021

Synthesis and characterization of a novel alkoxy substituted gold(III) phthalocyanine

Cemre Bilal, Altuǧ Mert Sevim, Ahmet Gül^*

^*Corresponding author for this work

Department of Chemistry

Istanbul Technical University

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Gold(III) compounds have long been investigated for anti-cancer treatment. However, clinical use has often been hampered by their poor stability in solution. In the design of physiologically stable anticancer gold (III) complexes, promising tetrapyrrole derivatives such as phthalocyanines are rarely studied. In this work, a novel soluble symmetrical gold-(III) phthalocyanine (AuPc) complex bearing four pentyloxy terminal moieties was prepared from metal-free phthalocyanine precursor in dioxane in the presence of K[AuCl4] and sodium acetate/acetic acid buffer. The new gold(III) complex obtained from this metallation was characterized by using elemental analyses, UV-Vis, FTIR, 1H NMR and mass spectroscopic data. The aggregative properties of the novel compound were.

Original language	English
Pages (from-to)	10-12
Number of pages	3
Journal	Inorganic Chemistry Communications
Volume	69
DOIs	https://doi.org/10.1016/j.inoche.2016.04.021
Publication status	Published - 1 Jul 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.

Funding

This work was supported by the Research Fund of the Technical University of Istanbul (Grant number 38097 ). AG thanks Turkish Academy of Sciences (TUBA) for partial support.

Funders	Funder number
Technical University of Istanbul	38097

Keywords

Aggregation
Gold
Metallation
Pentyloxy
Phthalocyanine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.inoche.2016.04.021

Cite this

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title = "Synthesis and characterization of a novel alkoxy substituted gold(III) phthalocyanine",

abstract = "Gold(III) compounds have long been investigated for anti-cancer treatment. However, clinical use has often been hampered by their poor stability in solution. In the design of physiologically stable anticancer gold (III) complexes, promising tetrapyrrole derivatives such as phthalocyanines are rarely studied. In this work, a novel soluble symmetrical gold-(III) phthalocyanine (AuPc) complex bearing four pentyloxy terminal moieties was prepared from metal-free phthalocyanine precursor in dioxane in the presence of K[AuCl4] and sodium acetate/acetic acid buffer. The new gold(III) complex obtained from this metallation was characterized by using elemental analyses, UV-Vis, FTIR, 1H NMR and mass spectroscopic data. The aggregative properties of the novel compound were.",

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AU - Bilal, Cemre

AU - Sevim, Altuǧ Mert

AU - Gül, Ahmet

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Y1 - 2016/7/1

N2 - Gold(III) compounds have long been investigated for anti-cancer treatment. However, clinical use has often been hampered by their poor stability in solution. In the design of physiologically stable anticancer gold (III) complexes, promising tetrapyrrole derivatives such as phthalocyanines are rarely studied. In this work, a novel soluble symmetrical gold-(III) phthalocyanine (AuPc) complex bearing four pentyloxy terminal moieties was prepared from metal-free phthalocyanine precursor in dioxane in the presence of K[AuCl4] and sodium acetate/acetic acid buffer. The new gold(III) complex obtained from this metallation was characterized by using elemental analyses, UV-Vis, FTIR, 1H NMR and mass spectroscopic data. The aggregative properties of the novel compound were.

AB - Gold(III) compounds have long been investigated for anti-cancer treatment. However, clinical use has often been hampered by their poor stability in solution. In the design of physiologically stable anticancer gold (III) complexes, promising tetrapyrrole derivatives such as phthalocyanines are rarely studied. In this work, a novel soluble symmetrical gold-(III) phthalocyanine (AuPc) complex bearing four pentyloxy terminal moieties was prepared from metal-free phthalocyanine precursor in dioxane in the presence of K[AuCl4] and sodium acetate/acetic acid buffer. The new gold(III) complex obtained from this metallation was characterized by using elemental analyses, UV-Vis, FTIR, 1H NMR and mass spectroscopic data. The aggregative properties of the novel compound were.

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KW - Gold

KW - Metallation

KW - Pentyloxy

KW - Phthalocyanine

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JO - Inorganic Chemistry Communications

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Synthesis and characterization of a novel alkoxy substituted gold(III) phthalocyanine

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

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