Abstract
The detection of chemicals in gas-phase has been employed in a wide variety of applications, including indoor air quality and environmental monitoring, chemical and biochemical processing, and medical diagnostics such as lung cancer screening. In this study, gold nanorod (AuNR) and silver nanocube (AgNC) molecules were functionalized with thiol (S- terminal) containing Calix[4]arene and were investigated for their molecular recognition properties on surface acoustic wave (SAW) transducer device surfaces. These novel sensing materials on transducer SAW device were investigated for the detection of polar (acetone, ethanol, chloroform, and humidity) and nonpolar (n-hexane, toluene, isoprene) volatile organic compounds (VOCs), among which are key markers for disease diagnosis, such as toluene present in exhaled breath of lung cancer patients. Sensor responses were discussed under various concentration levels in terms of selectivity, sensitivity, limit of detection, and response time. After AuNR and AgNC modification with Calix[4]arene, sensitivity of sensors has reached up to six to eight-fold higher than the individual responses, with a selectivity towards chloroform and toluene, respectively.
| Original language | English |
|---|---|
| Article number | 129402 |
| Journal | Sensors and Actuators, B: Chemical |
| Volume | 330 |
| DOIs | |
| Publication status | Published - 1 Mar 2021 |
Bibliographical note
Publisher Copyright:© 2020
Funding
Ilke GUROL received her BSc at Chemical and Metallurgical Engineering Faculty of Istanbul Technical University, Turkey. She is currently working as an associate professor at TUBITAK Marmara Research Center, Turkey. Her research interests are mainly based on synthesis and characterization of stable ligands, e.g. phthalocyanines, Schiff base’s, vic-dioximes with such functional groups as crown ether, aza ether, and thia ether functional groups, the synthesis of their alkaline and transition metal complexes and the investigation of their liquid crystal, semiconductor, photodynamic therapy (PDT) of cancer and chemical sensor properties by the structure of these macrocyclic compounds and biosensors applications. She is and has been involved in several research projects and networks funded by national bodies and COST project. She has published 48 papers, so far. This work was supported by the Scientific and Technological Research Council of Turkey (TÜBİTAK ARDEB) [Grant Number 115E045 ].
| Funders | Funder number |
|---|---|
| TÜBİTAK | |
| European Cooperation in Science and Technology | |
| Türkiye Bilimsel ve Teknolojik Araştirma Kurumu | 115E045 |
Keywords
- Calix[4]arene
- E-nose
- Gas sensor
- Lung cancer
- Surface acoustic wave (SAW)
- Volatile organic compounds (VOC)
