Superior Photodynamic Therapy of Colon Cancer Cells by Selenophene-BODIPY-Loaded Superparamagnetic Iron Oxide Nanoparticles

Kubra Nur Ozvural Sertcelik; Osman Karaman; Toghrul Almammadov; Gorkem Gunbas; Safacan Kolemen; Havva Yagci Acar; Kubra Onbasli

doi:10.1002/cptc.202200104

Superior Photodynamic Therapy of Colon Cancer Cells by Selenophene-BODIPY-Loaded Superparamagnetic Iron Oxide Nanoparticles

Kubra Nur Ozvural Sertcelik, Osman Karaman, Toghrul Almammadov, Gorkem Gunbas^*, Safacan Kolemen^*, Havva Yagci Acar^*, Kubra Onbasli^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Development of targeted nanoparticles as carriers to deliver photosensitizers to cancer cells is highly beneficial for ensuring the expected therapeutic outcome of photodynamic therapy. Herein, polyacrylic acid (PAA) coated superparamagnetic iron oxide nanoparticles (SPIONs), conjugated with endothelial growth factor receptor (EGFR) targeting Cetuximab (Cet) were loaded with a BODIPY-based (BOD-Se-I) photosensitizer (Cet-PAA@SPION/BOD-Se-I) to achieve enhanced and selective photodynamic therapy on colon cancer cells. In vitro studies showed that Cet-PAA@SPION/BOD-Se-I improved phototoxicity dramatically compared to free BOD-Se-I on the HT29 cell line due to high uptake of the photosensitizer via endothelial growth factor receptor. Most importantly, the developed nano-agent completely eliminated the phototoxicity of BOD-Se-I on the healthy L929 cell line.

Original language	English
Article number	e202200104
Journal	ChemPhotoChem
Volume	6
Issue number	10
DOIs	https://doi.org/10.1002/cptc.202200104
Publication status	Published - Oct 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 Wiley-VCH GmbH.

Keywords

BODIPY
colon cancer
iron oxide nanoparticles
photodynamic therapy
photosensitizers
superparamagnetism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cptc.202200104

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title = "Superior Photodynamic Therapy of Colon Cancer Cells by Selenophene-BODIPY-Loaded Superparamagnetic Iron Oxide Nanoparticles",

abstract = "Development of targeted nanoparticles as carriers to deliver photosensitizers to cancer cells is highly beneficial for ensuring the expected therapeutic outcome of photodynamic therapy. Herein, polyacrylic acid (PAA) coated superparamagnetic iron oxide nanoparticles (SPIONs), conjugated with endothelial growth factor receptor (EGFR) targeting Cetuximab (Cet) were loaded with a BODIPY-based (BOD-Se-I) photosensitizer (Cet-PAA@SPION/BOD-Se-I) to achieve enhanced and selective photodynamic therapy on colon cancer cells. In vitro studies showed that Cet-PAA@SPION/BOD-Se-I improved phototoxicity dramatically compared to free BOD-Se-I on the HT29 cell line due to high uptake of the photosensitizer via endothelial growth factor receptor. Most importantly, the developed nano-agent completely eliminated the phototoxicity of BOD-Se-I on the healthy L929 cell line.",

keywords = "BODIPY, colon cancer, iron oxide nanoparticles, photodynamic therapy, photosensitizers, superparamagnetism",

author = "{Ozvural Sertcelik}, {Kubra Nur} and Osman Karaman and Toghrul Almammadov and Gorkem Gunbas and Safacan Kolemen and {Yagci Acar}, Havva and Kubra Onbasli",

note = "Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",

year = "2022",

month = oct,

doi = "10.1002/cptc.202200104",

language = "English",

volume = "6",

journal = "ChemPhotoChem",

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AU - Ozvural Sertcelik, Kubra Nur

AU - Karaman, Osman

AU - Almammadov, Toghrul

AU - Gunbas, Gorkem

AU - Kolemen, Safacan

AU - Yagci Acar, Havva

AU - Onbasli, Kubra

PY - 2022/10

Y1 - 2022/10

N2 - Development of targeted nanoparticles as carriers to deliver photosensitizers to cancer cells is highly beneficial for ensuring the expected therapeutic outcome of photodynamic therapy. Herein, polyacrylic acid (PAA) coated superparamagnetic iron oxide nanoparticles (SPIONs), conjugated with endothelial growth factor receptor (EGFR) targeting Cetuximab (Cet) were loaded with a BODIPY-based (BOD-Se-I) photosensitizer (Cet-PAA@SPION/BOD-Se-I) to achieve enhanced and selective photodynamic therapy on colon cancer cells. In vitro studies showed that Cet-PAA@SPION/BOD-Se-I improved phototoxicity dramatically compared to free BOD-Se-I on the HT29 cell line due to high uptake of the photosensitizer via endothelial growth factor receptor. Most importantly, the developed nano-agent completely eliminated the phototoxicity of BOD-Se-I on the healthy L929 cell line.

AB - Development of targeted nanoparticles as carriers to deliver photosensitizers to cancer cells is highly beneficial for ensuring the expected therapeutic outcome of photodynamic therapy. Herein, polyacrylic acid (PAA) coated superparamagnetic iron oxide nanoparticles (SPIONs), conjugated with endothelial growth factor receptor (EGFR) targeting Cetuximab (Cet) were loaded with a BODIPY-based (BOD-Se-I) photosensitizer (Cet-PAA@SPION/BOD-Se-I) to achieve enhanced and selective photodynamic therapy on colon cancer cells. In vitro studies showed that Cet-PAA@SPION/BOD-Se-I improved phototoxicity dramatically compared to free BOD-Se-I on the HT29 cell line due to high uptake of the photosensitizer via endothelial growth factor receptor. Most importantly, the developed nano-agent completely eliminated the phototoxicity of BOD-Se-I on the healthy L929 cell line.

KW - BODIPY

KW - colon cancer

KW - iron oxide nanoparticles

KW - photodynamic therapy

KW - photosensitizers

KW - superparamagnetism

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DO - 10.1002/cptc.202200104

M3 - Article

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VL - 6

JO - ChemPhotoChem

JF - ChemPhotoChem

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ER -

Superior Photodynamic Therapy of Colon Cancer Cells by Selenophene-BODIPY-Loaded Superparamagnetic Iron Oxide Nanoparticles

Abstract

Bibliographical note

Keywords

UN SDGs

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