TY - JOUR
T1 - Sulfobetaine/Alginate/Chitosan Supported Hybrid N-Isopropylacrylamide Hydrogels
T2 - Composition-Dependent Diffusion/Compression Properties and Theophylline/Diclofenac Sodium/Ciprofloxacin Release Kinetics
AU - Şahin, Fatıma Cemre
AU - Şimşek, Ceyda
AU - Erbil, Candan
N1 - Publisher Copyright:
© 2024 Wiley Periodicals LLC.
PY - 2024
Y1 - 2024
N2 - Poly(N-isopropylacrylamide) (N), poly([3-(methacryloylamino)propyl] dimethyl(3-sulfopropyl) ammonium hydroxide) (SB) and SB/N hydrogels were prepared using N,N′-methylenebisacrylamide as crosslinker, while their hybrid semi-/full-IPNs N1A, N1C, N1CA, SB/N1A, SB/N1C, and SB/N1CA were synthesized in the presence of Alginate (A)/Chitosan (C). All the hydrogels were evaluated by taking into account their appearances, compression strengths and swelling behaviors in the ranges of pH 1.2–9.0 and temperature 4°C–40°C. The compressive moduli of N and SB/N hydrogels increased from ~10 to 80 kPa by changing composition (from N, SB/N to N1CA, SB/N1CA), swelling solution (from DDW to PBS) and temperature (from 25° to 37°C). The release profiles of diclofenac sodium (DFNa), theophylline (Thp), and ciprofloxacin (CIP) from N, SB/N, and their semi-/full-IPNs were investigated at pH 1.2 and pH 7.4, mimicking gastric and intestinal fluids. Higuchi, Peppas, and Weibull models were used, to describe the mechanisms of DFNa, Thp, and CIP releases from the hybrid IPNs of N and SB/N. The values of n (> 0.45) and β (> 0.75) at 37°C for Peppas and Weibull equations showed that DFNa and CIP releases from SB/N hybrids, which are more hydrophilic than IPNs of N, are mainly controlled by swelling/relaxation process.
AB - Poly(N-isopropylacrylamide) (N), poly([3-(methacryloylamino)propyl] dimethyl(3-sulfopropyl) ammonium hydroxide) (SB) and SB/N hydrogels were prepared using N,N′-methylenebisacrylamide as crosslinker, while their hybrid semi-/full-IPNs N1A, N1C, N1CA, SB/N1A, SB/N1C, and SB/N1CA were synthesized in the presence of Alginate (A)/Chitosan (C). All the hydrogels were evaluated by taking into account their appearances, compression strengths and swelling behaviors in the ranges of pH 1.2–9.0 and temperature 4°C–40°C. The compressive moduli of N and SB/N hydrogels increased from ~10 to 80 kPa by changing composition (from N, SB/N to N1CA, SB/N1CA), swelling solution (from DDW to PBS) and temperature (from 25° to 37°C). The release profiles of diclofenac sodium (DFNa), theophylline (Thp), and ciprofloxacin (CIP) from N, SB/N, and their semi-/full-IPNs were investigated at pH 1.2 and pH 7.4, mimicking gastric and intestinal fluids. Higuchi, Peppas, and Weibull models were used, to describe the mechanisms of DFNa, Thp, and CIP releases from the hybrid IPNs of N and SB/N. The values of n (> 0.45) and β (> 0.75) at 37°C for Peppas and Weibull equations showed that DFNa and CIP releases from SB/N hybrids, which are more hydrophilic than IPNs of N, are mainly controlled by swelling/relaxation process.
UR - http://www.scopus.com/inward/record.url?scp=85210940232&partnerID=8YFLogxK
U2 - 10.1002/app.56507
DO - 10.1002/app.56507
M3 - Article
AN - SCOPUS:85210940232
SN - 0021-8995
VL - 142
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
IS - 8
M1 - e56507
ER -