Study of competitive protein-drug binding by capillary electrophoresis

F. Bedia Erim Berker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The competitive affinity of two drugs (the anticoagulant warfarin and the diuretic furosemide) to bovine serum albumin (BSA) is studied by capillary electrophoresis. The competition of these two drugs for the same site on BSA is shown. The binding constant between the displacer drug (furosemide) and BSA is estimated relative to the known warfarin-BSA binding constant.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalBulletin of the Technical University of Istanbul
Issue number1
Publication statusPublished - May 2003


  • Binding constant
  • Capillary electrophoresis
  • Drug
  • Protein


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