Studies on kyotorphin and d-kyotorphin in aqueous solution by Raman spectroscopy

Sevim Akyuz*, Gonul Basar, Gunay Basar, Seda Kin, Sophie Kröger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Raman spectra of kyotorphin [l-Tyr-l-Arg] and d-Kyotorphin [l-Tyr-d-Arg] dipeptides in water and heavy water solutions are reported for the first time in the 1800-200 cm-1 range. Vibrational assignments have been made for many of the observed frequencies on the basis of group frequency considerations as well as comparison with accepted assignments for certain vibrational modes in the amino acid residues of the dipeptides. Hydrogen bonded state of the tyrosine phenoxyl group was found to change depending on the concentration, and H2O/D2O of the aqueous solutions of kyotorphin analogues. Investigation of the amide I and amide III bands of kyotorphin analogues indicates conformational alteration depending on either phases (solid or aqueous solution; in the case of KTP) or on deuteration of the solution (H2O/D2O; in the case of d-KTP).

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalJournal of Molecular Structure
Issue numberC
Publication statusPublished - 30 Apr 2009


This project is supported by the Scientific and Technological Research Council of Turkey under the project number 105T482. One of us (Gonul Basar) thanks the Research Fund of the University of Istanbul for financial support (project number 1649 and UDP 2499).

FundersFunder number
University of IstanbulUDP 2499, 1649
National Council for Scientific Research105T482


    • Amino acids
    • Arginine
    • Dipeptides
    • Kyotorphin
    • Raman spectra
    • Tyrosine


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