Spectroscopic and thermodynamic approach to the interaction of nonperipherally substituted cationic phthalocyanines with calf thymus (CT)-DNA

Sevgican Tuncer; Ibrahim Ozçeşmeci; Behice Şebnem Sesalan; Ayfer Kalkan Burat

doi:10.3906/kim-1705-59

Spectroscopic and thermodynamic approach to the interaction of nonperipherally substituted cationic phthalocyanines with calf thymus (CT)-DNA

Sevgican Tuncer, Ibrahim Ozçeşmeci, Behice Şebnem Sesalan, Ayfer Kalkan Burat^*

^*Corresponding author for this work

Department of Chemistry

Istanbul Technical University

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Novel, nonperipherally tetrasubstituted cationic metal-free and metallophthalocyanines (Zn, In) were synthesized in the present study. The binding constants, the disappearance of quenching effect of all cationic phthalocyanines on the fluorescence intensity of SYBR Green–disodium salt of deoxyribonucleic acid (DNA) from calf thymus complex, and the changes in Tm of double helix DNA with thermal denaturation profile were investigated by UV-Vis and fluorescence spectrophotometric methods. To investigate the spontaneity of the reactions between DNA and novel quaternized phthalocyanines in buffer, thermodynamic parameters were employed.

Original language	English
Pages (from-to)	274-290
Number of pages	17
Journal	Turkish Journal of Chemistry
Volume	42
Issue number	2
DOIs	https://doi.org/10.3906/kim-1705-59
Publication status	Published - 2018

Bibliographical note

Publisher Copyright:
© TÜBITAK.

Funding

This work was supported by the Scientific and Technological Research Council of Turkey (TÜBİTAK, Project no: 115Z063).

Funders	Funder number
TÜBİTAK
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu	115Z063

Keywords

Calf thymus (CT)-DNA
Entropy
Gibbs
Morpholine
Quaternized phthalocyanines

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10.3906/kim-1705-59

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abstract = "Novel, nonperipherally tetrasubstituted cationic metal-free and metallophthalocyanines (Zn, In) were synthesized in the present study. The binding constants, the disappearance of quenching effect of all cationic phthalocyanines on the fluorescence intensity of SYBR Green–disodium salt of deoxyribonucleic acid (DNA) from calf thymus complex, and the changes in Tm of double helix DNA with thermal denaturation profile were investigated by UV-Vis and fluorescence spectrophotometric methods. To investigate the spontaneity of the reactions between DNA and novel quaternized phthalocyanines in buffer, thermodynamic parameters were employed.",

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doi = "10.3906/kim-1705-59",

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T1 - Spectroscopic and thermodynamic approach to the interaction of nonperipherally substituted cationic phthalocyanines with calf thymus (CT)-DNA

AU - Tuncer, Sevgican

AU - Ozçeşmeci, Ibrahim

AU - Sesalan, Behice Şebnem

AU - Kalkan Burat, Ayfer

N1 - Publisher Copyright: © TÜBITAK.

PY - 2018

Y1 - 2018

N2 - Novel, nonperipherally tetrasubstituted cationic metal-free and metallophthalocyanines (Zn, In) were synthesized in the present study. The binding constants, the disappearance of quenching effect of all cationic phthalocyanines on the fluorescence intensity of SYBR Green–disodium salt of deoxyribonucleic acid (DNA) from calf thymus complex, and the changes in Tm of double helix DNA with thermal denaturation profile were investigated by UV-Vis and fluorescence spectrophotometric methods. To investigate the spontaneity of the reactions between DNA and novel quaternized phthalocyanines in buffer, thermodynamic parameters were employed.

AB - Novel, nonperipherally tetrasubstituted cationic metal-free and metallophthalocyanines (Zn, In) were synthesized in the present study. The binding constants, the disappearance of quenching effect of all cationic phthalocyanines on the fluorescence intensity of SYBR Green–disodium salt of deoxyribonucleic acid (DNA) from calf thymus complex, and the changes in Tm of double helix DNA with thermal denaturation profile were investigated by UV-Vis and fluorescence spectrophotometric methods. To investigate the spontaneity of the reactions between DNA and novel quaternized phthalocyanines in buffer, thermodynamic parameters were employed.

KW - Calf thymus (CT)-DNA

KW - Entropy

KW - Gibbs

KW - Morpholine

KW - Quaternized phthalocyanines

UR - https://www.scopus.com/pages/publications/85048033501

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DO - 10.3906/kim-1705-59

M3 - Article

AN - SCOPUS:85048033501

SN - 1300-0527

VL - 42

SP - 274

EP - 290

JO - Turkish Journal of Chemistry

JF - Turkish Journal of Chemistry

IS - 2

ER -

Spectroscopic and thermodynamic approach to the interaction of nonperipherally substituted cationic phthalocyanines with calf thymus (CT)-DNA

Abstract

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Keywords

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