Spectroscopic and thermodynamic approach to the interaction of nonperipherally substituted cationic phthalocyanines with calf thymus (CT)-DNA

Sevgican Tuncer, Ibrahim Ozçeşmeci, Behice Şebnem Sesalan, Ayfer Kalkan Burat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Novel, nonperipherally tetrasubstituted cationic metal-free and metallophthalocyanines (Zn, In) were synthesized in the present study. The binding constants, the disappearance of quenching effect of all cationic phthalocyanines on the fluorescence intensity of SYBR Green–disodium salt of deoxyribonucleic acid (DNA) from calf thymus complex, and the changes in Tm of double helix DNA with thermal denaturation profile were investigated by UV-Vis and fluorescence spectrophotometric methods. To investigate the spontaneity of the reactions between DNA and novel quaternized phthalocyanines in buffer, thermodynamic parameters were employed.

Original languageEnglish
Pages (from-to)274-290
Number of pages17
JournalTurkish Journal of Chemistry
Volume42
Issue number2
DOIs
Publication statusPublished - 2018

Bibliographical note

Publisher Copyright:
© TÜBITAK.

Funding

This work was supported by the Scientific and Technological Research Council of Turkey (TÜBİTAK, Project no: 115Z063).

FundersFunder number
TÜBİTAK
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu115Z063

    Keywords

    • Calf thymus (CT)-DNA
    • Entropy
    • Gibbs
    • Morpholine
    • Quaternized phthalocyanines

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