Spectrophotometric determination of metoprolol tartrate in pharmaceutical dosage forms on complex formation with Cu(II)

Mustafa Cesme; Derya Tarinc; Aysegul Golcu

doi:10.3390/ph4070964

Spectrophotometric determination of metoprolol tartrate in pharmaceutical dosage forms on complex formation with Cu(II)

Mustafa Cesme^*, Derya Tarinc, Aysegul Golcu

^*Corresponding author for this work

Kahramanmaras Sutcu Imam University

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A new, simple, sensitive and accurate spectrophotometric method has been developed for the assay of metoprolol tartrate (MPT), which is based on the complexation of drug with copper(II) [Cu(II)] at pH 6.0, using Britton-Robinson buffer solution, to produce a blue adduct. The latter has a maximum absorbance at 675 nm and obeys Beer's law within the concentration range 8.5-70 μg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.998) with a limit of detection of 5.56 μg/mL. The proposed procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copper(II) complex of MPT (Cu₂MPT₂Cl₂) have been reported.

Original language	English
Pages (from-to)	964-975
Number of pages	12
Journal	Pharmaceuticals
Volume	4
Issue number	7
DOIs	https://doi.org/10.3390/ph4070964
Publication status	Published - 2011
Externally published	Yes

Keywords

B-blockers
Complexation
Metoprolol
Spectrophotometry

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10.3390/ph4070964

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title = "Spectrophotometric determination of metoprolol tartrate in pharmaceutical dosage forms on complex formation with Cu(II)",

abstract = "A new, simple, sensitive and accurate spectrophotometric method has been developed for the assay of metoprolol tartrate (MPT), which is based on the complexation of drug with copper(II) [Cu(II)] at pH 6.0, using Britton-Robinson buffer solution, to produce a blue adduct. The latter has a maximum absorbance at 675 nm and obeys Beer's law within the concentration range 8.5-70 μg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.998) with a limit of detection of 5.56 μg/mL. The proposed procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copper(II) complex of MPT (Cu2MPT2Cl2) have been reported.",

keywords = "B-blockers, Complexation, Metoprolol, Spectrophotometry",

author = "Mustafa Cesme and Derya Tarinc and Aysegul Golcu",

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volume = "4",

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journal = "Pharmaceuticals",

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TY - JOUR

T1 - Spectrophotometric determination of metoprolol tartrate in pharmaceutical dosage forms on complex formation with Cu(II)

AU - Cesme, Mustafa

AU - Tarinc, Derya

AU - Golcu, Aysegul

PY - 2011

Y1 - 2011

N2 - A new, simple, sensitive and accurate spectrophotometric method has been developed for the assay of metoprolol tartrate (MPT), which is based on the complexation of drug with copper(II) [Cu(II)] at pH 6.0, using Britton-Robinson buffer solution, to produce a blue adduct. The latter has a maximum absorbance at 675 nm and obeys Beer's law within the concentration range 8.5-70 μg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.998) with a limit of detection of 5.56 μg/mL. The proposed procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copper(II) complex of MPT (Cu2MPT2Cl2) have been reported.

AB - A new, simple, sensitive and accurate spectrophotometric method has been developed for the assay of metoprolol tartrate (MPT), which is based on the complexation of drug with copper(II) [Cu(II)] at pH 6.0, using Britton-Robinson buffer solution, to produce a blue adduct. The latter has a maximum absorbance at 675 nm and obeys Beer's law within the concentration range 8.5-70 μg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.998) with a limit of detection of 5.56 μg/mL. The proposed procedure has been successfully applied to the determination of this drug in its tablets. In addition, the spectral data and stability constant for the binuclear copper(II) complex of MPT (Cu2MPT2Cl2) have been reported.

KW - B-blockers

KW - Complexation

KW - Metoprolol

KW - Spectrophotometry

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U2 - 10.3390/ph4070964

DO - 10.3390/ph4070964

M3 - Article

AN - SCOPUS:80051654244

SN - 1424-8247

VL - 4

SP - 964

EP - 975

JO - Pharmaceuticals

JF - Pharmaceuticals

IS - 7

ER -

Spectrophotometric determination of metoprolol tartrate in pharmaceutical dosage forms on complex formation with Cu(II)

Abstract

Keywords

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