Spectrophotometric determination of furosemide in pharmaceutical dosage forms using complex formation with Cu(II)

A. Gölcü

doi:10.1134/S1061934806080053

Spectrophotometric determination of furosemide in pharmaceutical dosage forms using complex formation with Cu(II)

A. Gölcü^*

^*Corresponding author for this work

Kahramanmaras Sutcu Imam University

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

A simple, sensitive, and accurate spectrophotometric method has been developed for the assay of furosemide (FUR), which is based on the complexation of the drug with copper(II) at pH 3.2 using Mclivaine buffer solution to produce a green adduct. The latter has maximum absorbance at 790 nm and obeys Beer's law within the concentration range 5-30 μg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.9997) with minimum detection limit of 0.23 μg/mL. The proposed procedure has been successfully applied to the determination of this drug in tablets. In addition, the spectral data and stability constant for the mononuclear copper(II) complex of furosemide (CuFUR₂(MeOH)₂) are reported.

Original language	English
Pages (from-to)	748-754
Number of pages	7
Journal	Journal of Analytical Chemistry
Volume	61
Issue number	8
DOIs	https://doi.org/10.1134/S1061934806080053
Publication status	Published - Aug 2006
Externally published	Yes

Funding

ACKNOWLEDGMENTS The author gratefully acknowledges the financial support of the Research Foundation (project no. 2004-4/6) of Kahramanmaras¸ Sütçü ˙mam University, Kahr-amanmaras¸, Turkey, and thanks Prof. Dr. Selahattin Serin, Prof. Dr. Sibel A. Ozkan, and Chem. Mustafa Dolaz for their useful suggestions.

Funders	Funder number
ASCRS Research Foundation	2004-4/6

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abstract = "A simple, sensitive, and accurate spectrophotometric method has been developed for the assay of furosemide (FUR), which is based on the complexation of the drug with copper(II) at pH 3.2 using Mclivaine buffer solution to produce a green adduct. The latter has maximum absorbance at 790 nm and obeys Beer's law within the concentration range 5-30 μg/mL. Regression analysis of the calibration data showed a good correlation coefficient (r = 0.9997) with minimum detection limit of 0.23 μg/mL. The proposed procedure has been successfully applied to the determination of this drug in tablets. In addition, the spectral data and stability constant for the mononuclear copper(II) complex of furosemide (CuFUR2(MeOH)2) are reported.",

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Spectrophotometric determination of furosemide in pharmaceutical dosage forms using complex formation with Cu(II)

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