Spectral properties and photophysical behaviour of water soluble cationic Mg(II) and Al(III) phthalocyanines

Mopelola A. Idowu, Yasin Arslanoğlu, Tebello Nyokong

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6 Citations (Scopus)


Peripherally and non-peripherally tetrasubstituted-[(N-methyl-2- pyridylthio)]phthalocyaninato magnesium (II) (5 and 6) and chloro aluminium (III) (7 and 8) tetraiodide have been synthesized and characterized. The photophysical properties of the complexes in dimethyl sulfoxide (DMSO) and aqueous medium in the presence and absence of cremophore EL have been studied. These complexes show high solubility in aqueous medium though they were aggregated. The triplet state quantum yields (F T ) and the triplet lifetimes (t T ) were found to be higher in DMSO with Φ T ranging from 0.32 to 0.51, while t T ranged from 282 to 622 ms in DMSO, compared to aqueous medium (pH 7.4 buffer) where Φ T ranged from 0.15 to 0.19 and t T from 26 to 35 ms. Addition of cremophore EL in aqueous solution resulted in partial disaggregation and increased photoactivity. The fluorescence lifetimes of the complexes showed strong dependence on their immediate environment. The ionic magnesium(II) and aluminium(III) phthalocyanines strongly bind to bovine serum albumin (BSA).

Original languageEnglish
Pages (from-to)403-415
Number of pages13
JournalCentral European Journal of Chemistry
Issue number3
Publication statusPublished - Mar 2014


This work was supported by the Department of Science and Technology (DST) and National Research Foundation (NRF), South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology as well as Rhodes University. MI thanks FUNAAB for leave. YA thanks Istanbul Technical University, DPT and TUBITAK for leave.

FundersFunder number
National Research Foundation
Rhodes University
Department of Science and Technology, Government of Kerala


    • Aggregation
    • Fluorescence lifetime
    • Metallophthalocyanine
    • Photodynamic therapy
    • Water soluble


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