Sorting of micron-sized particles using holographic optical Raman tweezers in aqueous medium

Uğur Parlatan, Gönül Başar, Günay Başar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We have constructed a holographic optical tweezers system combined with Raman spectroscopy to sort trapped particles. Our software automatically moves the trapped objects to the measurement positions to obtain individual Raman signals from multiple trapped particles. We performed the sorting by comparing their spectra with the previously measured training dataset using the correlation coefficients. We used yeast cells and polystyrene beads as test particles. This study aims to show that biological particles can be separated using single cell analysis with combined holographic optical tweezers and Raman spectroscopy system.

Original languageEnglish
Pages (from-to)228-234
Number of pages7
JournalJournal of Modern Optics
Volume66
Issue number2
DOIs
Publication statusPublished - 19 Jan 2019

Bibliographical note

Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Funding

Gunay Basar and Ugur Parlatan are grateful to the support offered by Istanbul Technical University Scientific Research Fund (Project Nos: 38202 and 37851).

FundersFunder number
Istanbul Technical University Scientific Research Fund38202, 37851

    Keywords

    • Holographic optical tweezers
    • Raman spectroscopy
    • multivariate statistical analysis
    • particle sorting

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