SOD activity and DNA binding properties of a new symmetric porphyrin Schiff base ligand and its metal complexes

Sevim Çay; Muhammet Köse; Ferhan Tümer; Ayşegül Gölcü; Mehmet Tümer

doi:10.1016/j.saa.2015.07.044

SOD activity and DNA binding properties of a new symmetric porphyrin Schiff base ligand and its metal complexes

Sevim Çay, Muhammet Köse, Ferhan Tümer, Ayşegül Gölcü, Mehmet Tümer^*

^*Corresponding author for this work

Kahramanmaras Sutcu Imam University

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

4-Methoxy-2,6-bis(hydroxymethyl)phenol (1) was prepared from the reaction of 4-methoxyphenol and formaldehyde. The compound (1) was then oxidized to the 4-methoxy-2,6-diformylphenol (2) compound. Molecular structure of compound (2) was determined by X-ray diffraction method. A new symmetric porphyrin Schiff base ligand 4-methoxy-2,6-bis[5-(4-iminophenyl)-10,15,20-triphenylporphyrin]phenol (L) was prepared from the reaction of the 5-(4-aminophenyl)-10,15,20-triphenylporphyrin (TTP-NH₂) and the compound (2) in the toluene solution. The metal complexes (Cu(II), Fe(III), Mn(III), Pt(II) and Zn(II)) of the ligand (L) were synthesized and characterized by the spectroscopic and analytical methods. The DNA (fish sperm FSdsDNA) binding studies of the ligand and its complexes were performed using UV-vis spectroscopy. Additionally, superoxide dismutase activities of the porphyrin Schiff base metal complexes were investigated. Additionally, electrochemical, photoluminescence and thermal properties of the compounds were investigated.

Original language	English
Pages (from-to)	821-838
Number of pages	18
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	151
DOIs	https://doi.org/10.1016/j.saa.2015.07.044
Publication status	Published - 13 Jul 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.

Funding

We are grateful to The Scientific & Technological Research Council of Turkey (TUBITAK) (Project number: 113Z907) for the support of this research. The authors are also grateful to the Department of Chemistry, Loughborough University for X-ray data collection.

Funders	Funder number
TUBITAK	113Z907
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu

Keywords

DNA-binding
Porphyrin-Schiff base
Spectroscopy
Superoxide dismutase activity

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10.1016/j.saa.2015.07.044

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title = "SOD activity and DNA binding properties of a new symmetric porphyrin Schiff base ligand and its metal complexes",

abstract = "4-Methoxy-2,6-bis(hydroxymethyl)phenol (1) was prepared from the reaction of 4-methoxyphenol and formaldehyde. The compound (1) was then oxidized to the 4-methoxy-2,6-diformylphenol (2) compound. Molecular structure of compound (2) was determined by X-ray diffraction method. A new symmetric porphyrin Schiff base ligand 4-methoxy-2,6-bis[5-(4-iminophenyl)-10,15,20-triphenylporphyrin]phenol (L) was prepared from the reaction of the 5-(4-aminophenyl)-10,15,20-triphenylporphyrin (TTP-NH2) and the compound (2) in the toluene solution. The metal complexes (Cu(II), Fe(III), Mn(III), Pt(II) and Zn(II)) of the ligand (L) were synthesized and characterized by the spectroscopic and analytical methods. The DNA (fish sperm FSdsDNA) binding studies of the ligand and its complexes were performed using UV-vis spectroscopy. Additionally, superoxide dismutase activities of the porphyrin Schiff base metal complexes were investigated. Additionally, electrochemical, photoluminescence and thermal properties of the compounds were investigated.",

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T1 - SOD activity and DNA binding properties of a new symmetric porphyrin Schiff base ligand and its metal complexes

AU - Çay, Sevim

AU - Köse, Muhammet

AU - Tümer, Ferhan

AU - Gölcü, Ayşegül

AU - Tümer, Mehmet

PY - 2015/7/13

Y1 - 2015/7/13

N2 - 4-Methoxy-2,6-bis(hydroxymethyl)phenol (1) was prepared from the reaction of 4-methoxyphenol and formaldehyde. The compound (1) was then oxidized to the 4-methoxy-2,6-diformylphenol (2) compound. Molecular structure of compound (2) was determined by X-ray diffraction method. A new symmetric porphyrin Schiff base ligand 4-methoxy-2,6-bis[5-(4-iminophenyl)-10,15,20-triphenylporphyrin]phenol (L) was prepared from the reaction of the 5-(4-aminophenyl)-10,15,20-triphenylporphyrin (TTP-NH2) and the compound (2) in the toluene solution. The metal complexes (Cu(II), Fe(III), Mn(III), Pt(II) and Zn(II)) of the ligand (L) were synthesized and characterized by the spectroscopic and analytical methods. The DNA (fish sperm FSdsDNA) binding studies of the ligand and its complexes were performed using UV-vis spectroscopy. Additionally, superoxide dismutase activities of the porphyrin Schiff base metal complexes were investigated. Additionally, electrochemical, photoluminescence and thermal properties of the compounds were investigated.

AB - 4-Methoxy-2,6-bis(hydroxymethyl)phenol (1) was prepared from the reaction of 4-methoxyphenol and formaldehyde. The compound (1) was then oxidized to the 4-methoxy-2,6-diformylphenol (2) compound. Molecular structure of compound (2) was determined by X-ray diffraction method. A new symmetric porphyrin Schiff base ligand 4-methoxy-2,6-bis[5-(4-iminophenyl)-10,15,20-triphenylporphyrin]phenol (L) was prepared from the reaction of the 5-(4-aminophenyl)-10,15,20-triphenylporphyrin (TTP-NH2) and the compound (2) in the toluene solution. The metal complexes (Cu(II), Fe(III), Mn(III), Pt(II) and Zn(II)) of the ligand (L) were synthesized and characterized by the spectroscopic and analytical methods. The DNA (fish sperm FSdsDNA) binding studies of the ligand and its complexes were performed using UV-vis spectroscopy. Additionally, superoxide dismutase activities of the porphyrin Schiff base metal complexes were investigated. Additionally, electrochemical, photoluminescence and thermal properties of the compounds were investigated.

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KW - Porphyrin-Schiff base

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KW - Superoxide dismutase activity

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ER -

SOD activity and DNA binding properties of a new symmetric porphyrin Schiff base ligand and its metal complexes

Abstract

Bibliographical note

Funding

Keywords

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