TY - JOUR
T1 - Simultaneous polymerization-induced self-assembly (PISA) and guest molecule encapsulation
AU - Karagoz, Bunyamin
AU - Boyer, Cyrille
AU - Davis, Thomas P.
PY - 2014/2
Y1 - 2014/2
N2 - Nanoparticles with various morphologies such as micelles, worm-like/rod-like and spherical vesicles are made using a polymerization- induced self-assembly (PISA) approach via a one-pot RAFT dispersion polymerization. On polymerization/self-assembly, we report a concurrent highly efficient loading of guest molecules within the nanoparticle structures. Different nanoparticle morphologies, such as spherical micelles, worm-like, rod-like, and spherical vesicles, are achieved by gradually increasing the number-average degree of polymerization (DPn) of the PST block via increasing polymerization times (in a poor solvent) as determined by transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. In parallel, a guest molecule (Nile Red) is encapsulated during the polymerization without disturbing the morphology or the polymerization kinetics. A simultaneous encapsulation and self-assembly approach is described in this paper using a polymerization-induced self-assembly (PISA) approach via a one-pot RAFT dispersion polymerization. Nanoparticles with various morphologies such as spherical micelles, worm-like/rod-like and spherical vesicles are prepared.
AB - Nanoparticles with various morphologies such as micelles, worm-like/rod-like and spherical vesicles are made using a polymerization- induced self-assembly (PISA) approach via a one-pot RAFT dispersion polymerization. On polymerization/self-assembly, we report a concurrent highly efficient loading of guest molecules within the nanoparticle structures. Different nanoparticle morphologies, such as spherical micelles, worm-like, rod-like, and spherical vesicles, are achieved by gradually increasing the number-average degree of polymerization (DPn) of the PST block via increasing polymerization times (in a poor solvent) as determined by transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. In parallel, a guest molecule (Nile Red) is encapsulated during the polymerization without disturbing the morphology or the polymerization kinetics. A simultaneous encapsulation and self-assembly approach is described in this paper using a polymerization-induced self-assembly (PISA) approach via a one-pot RAFT dispersion polymerization. Nanoparticles with various morphologies such as spherical micelles, worm-like/rod-like and spherical vesicles are prepared.
KW - dispersion polymerization
KW - encapsulation
KW - living radical polymerization
KW - morphologies
KW - nanoparticles
KW - reversible addition fragmentation chain transfer (RAFT)
UR - http://www.scopus.com/inward/record.url?scp=84894066925&partnerID=8YFLogxK
U2 - 10.1002/marc.201300730
DO - 10.1002/marc.201300730
M3 - Article
C2 - 24259353
AN - SCOPUS:84894066925
SN - 1022-1336
VL - 35
SP - 417
EP - 421
JO - Macromolecular Rapid Communications
JF - Macromolecular Rapid Communications
IS - 4
ER -