Reversible molecular adsorption based on multiple-point interaction by shrinkable gels

Taro Oya; Takashi Enoki; Alexander Yu Grosberg; Satoru Masamune; Takaharu Sakiyama; Yukikazu Takeoka; Kazunori Tanaka; Guoqiang Wang; Yasar Yilmaz; Michael S. Feld; Ramachandra Dasari; Toyoichi Tanaka

doi:10.1126/science.286.5444.1543

Reversible molecular adsorption based on multiple-point interaction by shrinkable gels

Taro Oya, Takashi Enoki, Alexander Yu Grosberg, Satoru Masamune, Takaharu Sakiyama, Yukikazu Takeoka, Kazunori Tanaka, Guoqiang Wang, Yasar Yilmaz, Michael S. Feld, Ramachandra Dasari, Toyoichi Tanaka^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

188 Citations (Scopus)

Abstract

A general approach is presented for creating polymer gels that can recognize and capture a target molecule by multiple-point interaction and that can reversibly change their affinity to the target by more than one order of magnitude. The polymers consist of majority monomers that make the gel reversibly swell and shrink and minority monomers that constitute multiple-point adsorption centers for the target molecule. Multiple-point interaction is experimentally proven by power laws found between the affinity and the concentration of the adsorbing monomers within the gels.

Original language	English
Pages (from-to)	1543-1545
Number of pages	3
Journal	Science
Volume	286
Issue number	5444
DOIs	https://doi.org/10.1126/science.286.5444.1543
Publication status	Published - 19 Nov 1999
Externally published	Yes

Access to Document

10.1126/science.286.5444.1543

Cite this

@article{1755f48c1e8c4ff6815875fb025a0d0c,

title = "Reversible molecular adsorption based on multiple-point interaction by shrinkable gels",

abstract = "A general approach is presented for creating polymer gels that can recognize and capture a target molecule by multiple-point interaction and that can reversibly change their affinity to the target by more than one order of magnitude. The polymers consist of majority monomers that make the gel reversibly swell and shrink and minority monomers that constitute multiple-point adsorption centers for the target molecule. Multiple-point interaction is experimentally proven by power laws found between the affinity and the concentration of the adsorbing monomers within the gels.",

author = "Taro Oya and Takashi Enoki and Grosberg, {Alexander Yu} and Satoru Masamune and Takaharu Sakiyama and Yukikazu Takeoka and Kazunori Tanaka and Guoqiang Wang and Yasar Yilmaz and Feld, {Michael S.} and Ramachandra Dasari and Toyoichi Tanaka",

year = "1999",

month = nov,

day = "19",

doi = "10.1126/science.286.5444.1543",

language = "English",

volume = "286",

pages = "1543--1545",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5444",

}

TY - JOUR

T1 - Reversible molecular adsorption based on multiple-point interaction by shrinkable gels

AU - Oya, Taro

AU - Enoki, Takashi

AU - Grosberg, Alexander Yu

AU - Masamune, Satoru

AU - Sakiyama, Takaharu

AU - Takeoka, Yukikazu

AU - Tanaka, Kazunori

AU - Wang, Guoqiang

AU - Yilmaz, Yasar

AU - Feld, Michael S.

AU - Dasari, Ramachandra

AU - Tanaka, Toyoichi

PY - 1999/11/19

Y1 - 1999/11/19

N2 - A general approach is presented for creating polymer gels that can recognize and capture a target molecule by multiple-point interaction and that can reversibly change their affinity to the target by more than one order of magnitude. The polymers consist of majority monomers that make the gel reversibly swell and shrink and minority monomers that constitute multiple-point adsorption centers for the target molecule. Multiple-point interaction is experimentally proven by power laws found between the affinity and the concentration of the adsorbing monomers within the gels.

AB - A general approach is presented for creating polymer gels that can recognize and capture a target molecule by multiple-point interaction and that can reversibly change their affinity to the target by more than one order of magnitude. The polymers consist of majority monomers that make the gel reversibly swell and shrink and minority monomers that constitute multiple-point adsorption centers for the target molecule. Multiple-point interaction is experimentally proven by power laws found between the affinity and the concentration of the adsorbing monomers within the gels.

UR - http://www.scopus.com/inward/record.url?scp=13044317269&partnerID=8YFLogxK

U2 - 10.1126/science.286.5444.1543

DO - 10.1126/science.286.5444.1543

M3 - Article

C2 - 10567256

AN - SCOPUS:13044317269

SN - 0036-8075

VL - 286

SP - 1543

EP - 1545

JO - Science

JF - Science

IS - 5444

ER -

Reversible molecular adsorption based on multiple-point interaction by shrinkable gels

Abstract

Access to Document

Other files and links

Fingerprint

Cite this