Realizing medium spiny neurons with a simple neuron model

Sami Utku Çelikok*, Neslihan Serap Şengör

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Striatal medium spiny neurons (MSNs) constitute input nuclei of the basal ganglia. Most well-known dichotomous of striatal MSNs stem from dopaminergic modulation of striatal processing. Dopamine modulates excitability in striatal MSNs with a complex underlying mechanism and lack of balance in this delicate system leads to pathologies such as Parkinson’s disease. On the contrary, investigation of such a system requires simple, but yet comprehensive models that are capable of capturing complex behaviour of MSNs. We propose a reduced-computational but biologically plausible model that mimics the cell dynamics of striatal D1- and D2-type MSNs with different levels of dopamine using data from a recent study. Proposed computational model shows good matches to the MSN responses and captures some essential features of MSNs such as first spike latencies, dopamine modulated state transitions and enhanced response to depolarizing input during dopamine intervention.

Original languageEnglish
Title of host publicationArtificial Neural Networks and Machine Learning - 25th International Conference on Artificial Neural Networks, ICANN 2016, Proceedings
EditorsAlessandro E.P. Villa, Paolo Masulli, Antonio Javier Pons Rivero
PublisherSpringer Verlag
Number of pages8
ISBN (Print)9783319447773
Publication statusPublished - 2016
Event25th International Conference on Artificial Neural Networks, ICANN 2016 - Barcelona, Spain
Duration: 6 Sept 20169 Sept 2016

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9886 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference25th International Conference on Artificial Neural Networks, ICANN 2016

Bibliographical note

Publisher Copyright:
© Springer International Publishing Switzerland 2016.


  • Dopamine
  • Electrophysiology
  • Medium spiny neurons
  • Simple model


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