PVP/flavonoid coprecipitation by supercritical antisolvent process

Gulay Ozkan, Paola Franco, Esra Capanoglu, Iolanda De Marco*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


To date, various delivery systems have been developed to improve chemical stability and increase the bioavailability of polyphenolic compounds. In the present study, the micronization of two flavonoids, quercetin and rutin, and their coprecipitation with polyvinylpyrrolidone (PVP) were studied using the supercritical antisolvent process (SAS). SAS process parameters were optimized with the aim of obtaining composite microspheres with controlled mean size and particle size distribution. Spherical microparticles (with mean diameters in the range between 0.47 and 9.52 μm for PVP/quercetin and in the range 0.84–8.17 μm for PVP/rutin) were precipitated, depending on the operating conditions. In correspondence of the best operating conditions, the entrapment efficiency in PVP, for both flavonoids, was 99.8% and the dissolution rate from the coprecipitated powders was 10 and 3.19 times faster compared to the dissolution rates of unprocessed flavonoids for quercetin and rutin, respectively.

Original languageEnglish
Article number107689
JournalChemical Engineering and Processing - Process Intensification
Publication statusPublished - Dec 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier B.V.


This work was supported by the Istanbul Technical University, Scientific Research Projects (BAP) Unit [project number MDK-2018-41359 ]. This work was supported by the Istanbul Technical University, Scientific Research Projects (BAP) Unit [project number MDK-2018-41359].

FundersFunder number
British Association for Psychopharmacology
Istanbul Teknik ÜniversitesiMDK-2018-41359


    • Coprecipitated microparticles
    • Polyphenols
    • Polyvinylpyrrolidone
    • Quercetin
    • Rutin
    • SAS process


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