Abstract
Amphiphilic graft copolymers having polysulfone (PSf) backbones and poly(ethylene glycol) (PEG) side chains were synthesized via reaction of an alkoxide formed from PEG and a base (sodium hydride) with chloromethylated polysulfone. The resulting polysulfone-graft-poly(ethylene glycol), PSf-g-PEG, materials were hydrophilic but water insoluble, rendering them potentially useful as biomaterial coatings. PSf-g-PEG films exhibited high resistance to protein adsorption and cell attachment. When used as an additive in PSf membranes prepared by immersion precipitation, the graft copolymer preferentially segregates to the membrane surface, delivering enhanced wettability, porosity and protein resistance compared to unmodified PSf membranes. The surface properties of PSf-g-PEG modified membranes render them desirable candidates for hemodialysis.
| Original language | English |
|---|---|
| Pages (from-to) | 856-865 |
| Number of pages | 10 |
| Journal | Biomaterials |
| Volume | 27 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Feb 2006 |
| Externally published | Yes |
Funding
Financial support for this work was provided by the US Office of Naval Research under award N00014-02-1-0343, and grant 1R0GM59870-01 from the National Institute of Health. This work made use of MRSEC Shared Experimental Facilities support by the National Science Foundation under Award no. DMR-0213282. Jane Y. Park acknowledges the support of the National Science Foundation through the Graduate Student Fellowship program.
| Funders | Funder number |
|---|---|
| National Institute of Health | |
| US Office of Naval Research | N00014-02-1-0343, 1R0GM59870-01 |
| National Science Foundation | |
| National Institute of General Medical Sciences | R01GM059870 |
Keywords
- Dialysis
- Membrane
- Polyethylene glycol
- Polysulfone
- Protein resistance
- Surface modification