Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes

Jane Y. Park; Metin H. Acar; Ariya Akthakul; William Kuhlman; Anne M. Mayes

doi:10.1016/j.biomaterials.2005.07.010

Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes

Jane Y. Park, Metin H. Acar, Ariya Akthakul, William Kuhlman, Anne M. Mayes^*

^*Corresponding author for this work

Massachusetts Institute of Technology

Research output: Contribution to journal › Article › peer-review

324 Citations (Scopus)

Abstract

Amphiphilic graft copolymers having polysulfone (PSf) backbones and poly(ethylene glycol) (PEG) side chains were synthesized via reaction of an alkoxide formed from PEG and a base (sodium hydride) with chloromethylated polysulfone. The resulting polysulfone-graft-poly(ethylene glycol), PSf-g-PEG, materials were hydrophilic but water insoluble, rendering them potentially useful as biomaterial coatings. PSf-g-PEG films exhibited high resistance to protein adsorption and cell attachment. When used as an additive in PSf membranes prepared by immersion precipitation, the graft copolymer preferentially segregates to the membrane surface, delivering enhanced wettability, porosity and protein resistance compared to unmodified PSf membranes. The surface properties of PSf-g-PEG modified membranes render them desirable candidates for hemodialysis.

Original language	English
Pages (from-to)	856-865
Number of pages	10
Journal	Biomaterials
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.biomaterials.2005.07.010
Publication status	Published - Feb 2006
Externally published	Yes

Keywords

Dialysis
Membrane
Polyethylene glycol
Polysulfone
Protein resistance
Surface modification

Access to Document

10.1016/j.biomaterials.2005.07.010

Cite this

@article{1023a7d9079d41e083c54e623285700a,

title = "Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes",

abstract = "Amphiphilic graft copolymers having polysulfone (PSf) backbones and poly(ethylene glycol) (PEG) side chains were synthesized via reaction of an alkoxide formed from PEG and a base (sodium hydride) with chloromethylated polysulfone. The resulting polysulfone-graft-poly(ethylene glycol), PSf-g-PEG, materials were hydrophilic but water insoluble, rendering them potentially useful as biomaterial coatings. PSf-g-PEG films exhibited high resistance to protein adsorption and cell attachment. When used as an additive in PSf membranes prepared by immersion precipitation, the graft copolymer preferentially segregates to the membrane surface, delivering enhanced wettability, porosity and protein resistance compared to unmodified PSf membranes. The surface properties of PSf-g-PEG modified membranes render them desirable candidates for hemodialysis.",

keywords = "Dialysis, Membrane, Polyethylene glycol, Polysulfone, Protein resistance, Surface modification",

author = "Park, {Jane Y.} and Acar, {Metin H.} and Ariya Akthakul and William Kuhlman and Mayes, {Anne M.}",

year = "2006",

month = feb,

doi = "10.1016/j.biomaterials.2005.07.010",

language = "English",

volume = "27",

pages = "856--865",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes

AU - Park, Jane Y.

AU - Acar, Metin H.

AU - Akthakul, Ariya

AU - Kuhlman, William

AU - Mayes, Anne M.

PY - 2006/2

Y1 - 2006/2

N2 - Amphiphilic graft copolymers having polysulfone (PSf) backbones and poly(ethylene glycol) (PEG) side chains were synthesized via reaction of an alkoxide formed from PEG and a base (sodium hydride) with chloromethylated polysulfone. The resulting polysulfone-graft-poly(ethylene glycol), PSf-g-PEG, materials were hydrophilic but water insoluble, rendering them potentially useful as biomaterial coatings. PSf-g-PEG films exhibited high resistance to protein adsorption and cell attachment. When used as an additive in PSf membranes prepared by immersion precipitation, the graft copolymer preferentially segregates to the membrane surface, delivering enhanced wettability, porosity and protein resistance compared to unmodified PSf membranes. The surface properties of PSf-g-PEG modified membranes render them desirable candidates for hemodialysis.

AB - Amphiphilic graft copolymers having polysulfone (PSf) backbones and poly(ethylene glycol) (PEG) side chains were synthesized via reaction of an alkoxide formed from PEG and a base (sodium hydride) with chloromethylated polysulfone. The resulting polysulfone-graft-poly(ethylene glycol), PSf-g-PEG, materials were hydrophilic but water insoluble, rendering them potentially useful as biomaterial coatings. PSf-g-PEG films exhibited high resistance to protein adsorption and cell attachment. When used as an additive in PSf membranes prepared by immersion precipitation, the graft copolymer preferentially segregates to the membrane surface, delivering enhanced wettability, porosity and protein resistance compared to unmodified PSf membranes. The surface properties of PSf-g-PEG modified membranes render them desirable candidates for hemodialysis.

KW - Dialysis

KW - Membrane

KW - Polyethylene glycol

KW - Polysulfone

KW - Protein resistance

KW - Surface modification

UR - http://www.scopus.com/inward/record.url?scp=26944495686&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2005.07.010

DO - 10.1016/j.biomaterials.2005.07.010

M3 - Article

C2 - 16105681

AN - SCOPUS:26944495686

SN - 0142-9612

VL - 27

SP - 856

EP - 865

JO - Biomaterials

JF - Biomaterials

IS - 6

ER -

Polysulfone-graft-poly(ethylene glycol) graft copolymers for surface modification of polysulfone membranes

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this