Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties

Ceyda Şimşek; Candan Erbil

doi:10.1080/00914037.2021.1960333

Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties

Ceyda Şimşek, Candan Erbil^*

^*Corresponding author for this work

Department of Chemistry

Istanbul Technical University

Research output: Contribution to journal › Article › peer-review

Abstract

pH-/temperature-sensitive ampholytic poly(N-isopropylacrylamide) (PNIPAAm) hydrogels containing N-[3-(dimethylamino)propyl]methacrylamide-itaconic acid (DMAPMAAm-IA) and DMAPMAAm-AMPS (2-acrylamido-2-methylpropane sulfonic acid) comonomer pairs have been designed and then synthesized. The results showed that (i) disk diameters and transparencies in the range of pH 2–12 increased only with increasing content of AMPS in the ampholytic NIPAAm/DMAPMAAm/AMPS hydrogels containing 10.0 mol % of DMAPMAAm + AMPS mixtures; (ii) maximum compressive strengths of NIPAAm/IA (62.5 ± 10.0 kPa) was higher than NIPAAm/AMPS (26.9 ± 1.1 kPa) hydrogels in DDW at 37 °C. (iii) In case of DFNa release, the decreasing values of n (≈0.30–0.50) indicated that ampholytic PNIPAAm hydrogels served as diffusion barrier.

Original language	English
Pages (from-to)	1148-1163
Number of pages	16
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	71
Issue number	15
DOIs	https://doi.org/10.1080/00914037.2021.1960333
Publication status	Published - 2022

Bibliographical note

Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.

Funding

This work was supported by the Scientific Research Project Coordination Center of Istanbul Technical University (ITU) (Scientific Research Project Fund with the Project number 38387). We thank Dr. Gökhan Göksu for guidance on MATLABTM calculations.

Funders	Funder number
Istanbul Teknik Üniversitesi	38387

Keywords

2-acrylamido-2-methylpropane sulfonic acid
ampholytic poly(N-isopropylacrylamide) hydrogels
compression modulus
diclofenac sodium release
dynamic swelling
N-[3-(dimethylamino)propyl] methacrylamideItaconic acid

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10.1080/00914037.2021.1960333

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title = "Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties",

abstract = "pH-/temperature-sensitive ampholytic poly(N-isopropylacrylamide) (PNIPAAm) hydrogels containing N-[3-(dimethylamino)propyl]methacrylamide-itaconic acid (DMAPMAAm-IA) and DMAPMAAm-AMPS (2-acrylamido-2-methylpropane sulfonic acid) comonomer pairs have been designed and then synthesized. The results showed that (i) disk diameters and transparencies in the range of pH 2–12 increased only with increasing content of AMPS in the ampholytic NIPAAm/DMAPMAAm/AMPS hydrogels containing 10.0 mol % of DMAPMAAm + AMPS mixtures; (ii) maximum compressive strengths of NIPAAm/IA (62.5 ± 10.0 kPa) was higher than NIPAAm/AMPS (26.9 ± 1.1 kPa) hydrogels in DDW at 37 °C. (iii) In case of DFNa release, the decreasing values of n (≈0.30–0.50) indicated that ampholytic PNIPAAm hydrogels served as diffusion barrier.",

keywords = "2-acrylamido-2-methylpropane sulfonic acid, ampholytic poly(N-isopropylacrylamide) hydrogels, compression modulus, diclofenac sodium release, dynamic swelling, N-[3-(dimethylamino)propyl] methacrylamideItaconic acid",

author = "Ceyda {\c S}im{\c s}ek and Candan Erbil",

note = "Publisher Copyright: {\textcopyright} 2021 Taylor & Francis Group, LLC.",

year = "2022",

doi = "10.1080/00914037.2021.1960333",

language = "English",

volume = "71",

pages = "1148--1163",

journal = "International Journal of Polymeric Materials and Polymeric Biomaterials",

issn = "0091-4037",

publisher = "Taylor and Francis Ltd.",

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T1 - Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties

AU - Şimşek, Ceyda

AU - Erbil, Candan

PY - 2022

Y1 - 2022

N2 - pH-/temperature-sensitive ampholytic poly(N-isopropylacrylamide) (PNIPAAm) hydrogels containing N-[3-(dimethylamino)propyl]methacrylamide-itaconic acid (DMAPMAAm-IA) and DMAPMAAm-AMPS (2-acrylamido-2-methylpropane sulfonic acid) comonomer pairs have been designed and then synthesized. The results showed that (i) disk diameters and transparencies in the range of pH 2–12 increased only with increasing content of AMPS in the ampholytic NIPAAm/DMAPMAAm/AMPS hydrogels containing 10.0 mol % of DMAPMAAm + AMPS mixtures; (ii) maximum compressive strengths of NIPAAm/IA (62.5 ± 10.0 kPa) was higher than NIPAAm/AMPS (26.9 ± 1.1 kPa) hydrogels in DDW at 37 °C. (iii) In case of DFNa release, the decreasing values of n (≈0.30–0.50) indicated that ampholytic PNIPAAm hydrogels served as diffusion barrier.

AB - pH-/temperature-sensitive ampholytic poly(N-isopropylacrylamide) (PNIPAAm) hydrogels containing N-[3-(dimethylamino)propyl]methacrylamide-itaconic acid (DMAPMAAm-IA) and DMAPMAAm-AMPS (2-acrylamido-2-methylpropane sulfonic acid) comonomer pairs have been designed and then synthesized. The results showed that (i) disk diameters and transparencies in the range of pH 2–12 increased only with increasing content of AMPS in the ampholytic NIPAAm/DMAPMAAm/AMPS hydrogels containing 10.0 mol % of DMAPMAAm + AMPS mixtures; (ii) maximum compressive strengths of NIPAAm/IA (62.5 ± 10.0 kPa) was higher than NIPAAm/AMPS (26.9 ± 1.1 kPa) hydrogels in DDW at 37 °C. (iii) In case of DFNa release, the decreasing values of n (≈0.30–0.50) indicated that ampholytic PNIPAAm hydrogels served as diffusion barrier.

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KW - compression modulus

KW - diclofenac sodium release

KW - dynamic swelling

KW - N-[3-(dimethylamino)propyl] methacrylamideItaconic acid

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ER -

Poly(N-isopropylacrylamide) based pH- and temperature-sensitive ampholytic hydrogels with tunable mechanical, swelling and drug release properties

Abstract

Bibliographical note

Funding

Keywords

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