Polymeric Thioxanthones as Potential Anticancer and Radiotherapy Agents

Gorkem Yilmaz, Emine Guler, Firat Baris Barlas, Suna Timur, Yusuf Yagci

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Thioxanthone (TX) and its derivatives, which are widely used as photoinitiators in UV curing technology, hold promising research interest in biological applications. In particular, the use of TXs as anticancer agent has recently been manifested as an outstanding additional property of this class of molecules. Incorporation of TX molecules into specially designed polymers widens their practical use in such applications. In this study, two water-soluble, biocompatible, and stable polymers, namely poly(vinyl alcohol) and poly(ethylene glycol), possessing TX moieties at the side chains and chain ends, respectively, are prepared and used as anticancer and radiotherapy agents. The findings confirm that both polymers are potential candidates for therapeutic agents as they possess useful features including water-solubility, radiosensitizer effect, and anticancer activity in a polymeric scaffold.

Original languageEnglish
Pages (from-to)1046-1051
Number of pages6
JournalMacromolecular Rapid Communications
Issue number13
Publication statusPublished - 1 Jul 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


  • anticancer
  • cytotoxicity
  • poly(ethylene glycol)
  • poly(vinyl alcohol)
  • radiotherapy
  • thioxanthones


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