Polymeric hollow fiber membrane oxygenators as artificial lungs: A review

Oğuz Orhun Teber; Ayşegül Derya Altinay; Seyed Ali Naziri Mehrabani; Reyhan Sengur Tasdemir; Bihter Zeytuncu; Esra Ateş Genceli; Ebru Dulekgurgen; Kerem Pekkan; İsmail Koyuncu

doi:10.1016/j.bej.2022.108340

Polymeric hollow fiber membrane oxygenators as artificial lungs: A review

Oğuz Orhun Teber
, Ayşegül Derya Altinay
, Seyed Ali Naziri Mehrabani
, Reyhan Sengur Tasdemir
, Bihter Zeytuncu
, Esra Ateş Genceli
, Ebru Dulekgurgen
, Kerem Pekkan
, İsmail Koyuncu^*

^*Corresponding author for this work

Istanbul Technical University
Koc University

Research output: Contribution to journal › Review article › peer-review

58 Citations (Scopus)

Abstract

The oxygenator is one of the most important components of respiratory support devices, which began as a heart-lung machine for the treatment of heart diseases. Hollow fiber membranes have been widely used in oxygenators due to their outstanding performance in oxygen and carbon dioxide exchange with the blood. In this review, general information on the oxygenator historical evolutions is summarized. Then, the advantages and usage of hollow fiber membranes as oxygenators are explained. Modification strategies to prevent platelet adhesion, plasma leakage have been summarized. There has been some information given on design parameters for hollow fiber membrane oxygenators. In recent years, the rapid development of microchannel structures in oxygenators has been summarized. It is thought that this review will help the reader to find recent studies on the subject.

Original language	English
Article number	108340
Journal	Biochemical Engineering Journal
Volume	180
DOIs	https://doi.org/10.1016/j.bej.2022.108340
Publication status	Published - Mar 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier B.V.

Funding

This study is supported by TUBITAK (The Scientific and Technological Research Council of Turkey) 118S108 ( 118S109 ) Grant Numbers.

Funders	Funder number
TUBITAK
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu	118S108, 118S109

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Artificial lung
Hollow fiber
Membrane oxygenation
Modification
Oxygenator

Access to Document

10.1016/j.bej.2022.108340

Cite this

@article{08f9a6101e354f4184d7d452880ed273,

title = "Polymeric hollow fiber membrane oxygenators as artificial lungs: A review",

abstract = "The oxygenator is one of the most important components of respiratory support devices, which began as a heart-lung machine for the treatment of heart diseases. Hollow fiber membranes have been widely used in oxygenators due to their outstanding performance in oxygen and carbon dioxide exchange with the blood. In this review, general information on the oxygenator historical evolutions is summarized. Then, the advantages and usage of hollow fiber membranes as oxygenators are explained. Modification strategies to prevent platelet adhesion, plasma leakage have been summarized. There has been some information given on design parameters for hollow fiber membrane oxygenators. In recent years, the rapid development of microchannel structures in oxygenators has been summarized. It is thought that this review will help the reader to find recent studies on the subject.",

keywords = "Artificial lung, Hollow fiber, Membrane oxygenation, Modification, Oxygenator",

author = "Teber, \{Oğuz Orhun\} and Altinay, \{Ay{\c s}eg{\"u}l Derya\} and Mehrabani, \{Seyed Ali Naziri\} and Tasdemir, \{Reyhan Sengur\} and Bihter Zeytuncu and Genceli, \{Esra Ate{\c s}\} and Ebru Dulekgurgen and Kerem Pekkan and İsmail Koyuncu",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = mar,

doi = "10.1016/j.bej.2022.108340",

language = "English",

volume = "180",

journal = "Biochemical Engineering Journal",

issn = "1369-703X",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Polymeric hollow fiber membrane oxygenators as artificial lungs

T2 - A review

AU - Teber, Oğuz Orhun

AU - Altinay, Ayşegül Derya

AU - Mehrabani, Seyed Ali Naziri

AU - Tasdemir, Reyhan Sengur

AU - Zeytuncu, Bihter

AU - Genceli, Esra Ateş

AU - Dulekgurgen, Ebru

AU - Pekkan, Kerem

AU - Koyuncu, İsmail

PY - 2022/3

Y1 - 2022/3

N2 - The oxygenator is one of the most important components of respiratory support devices, which began as a heart-lung machine for the treatment of heart diseases. Hollow fiber membranes have been widely used in oxygenators due to their outstanding performance in oxygen and carbon dioxide exchange with the blood. In this review, general information on the oxygenator historical evolutions is summarized. Then, the advantages and usage of hollow fiber membranes as oxygenators are explained. Modification strategies to prevent platelet adhesion, plasma leakage have been summarized. There has been some information given on design parameters for hollow fiber membrane oxygenators. In recent years, the rapid development of microchannel structures in oxygenators has been summarized. It is thought that this review will help the reader to find recent studies on the subject.

AB - The oxygenator is one of the most important components of respiratory support devices, which began as a heart-lung machine for the treatment of heart diseases. Hollow fiber membranes have been widely used in oxygenators due to their outstanding performance in oxygen and carbon dioxide exchange with the blood. In this review, general information on the oxygenator historical evolutions is summarized. Then, the advantages and usage of hollow fiber membranes as oxygenators are explained. Modification strategies to prevent platelet adhesion, plasma leakage have been summarized. There has been some information given on design parameters for hollow fiber membrane oxygenators. In recent years, the rapid development of microchannel structures in oxygenators has been summarized. It is thought that this review will help the reader to find recent studies on the subject.

KW - Artificial lung

KW - Hollow fiber

KW - Membrane oxygenation

KW - Modification

KW - Oxygenator

UR - https://www.scopus.com/pages/publications/85123106041

U2 - 10.1016/j.bej.2022.108340

DO - 10.1016/j.bej.2022.108340

M3 - Review article

AN - SCOPUS:85123106041

SN - 1369-703X

VL - 180

JO - Biochemical Engineering Journal

JF - Biochemical Engineering Journal

M1 - 108340

ER -

Polymeric hollow fiber membrane oxygenators as artificial lungs: A review

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

Access to Document

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Cite this