Polymeric hollow fiber membrane oxygenators as artificial lungs: A review

Oğuz Orhun Teber, Ayşegül Derya Altinay, Seyed Ali Naziri Mehrabani, Reyhan Sengur Tasdemir, Bihter Zeytuncu, Esra Ateş Genceli, Ebru Dulekgurgen, Kerem Pekkan, İsmail Koyuncu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

The oxygenator is one of the most important components of respiratory support devices, which began as a heart-lung machine for the treatment of heart diseases. Hollow fiber membranes have been widely used in oxygenators due to their outstanding performance in oxygen and carbon dioxide exchange with the blood. In this review, general information on the oxygenator historical evolutions is summarized. Then, the advantages and usage of hollow fiber membranes as oxygenators are explained. Modification strategies to prevent platelet adhesion, plasma leakage have been summarized. There has been some information given on design parameters for hollow fiber membrane oxygenators. In recent years, the rapid development of microchannel structures in oxygenators has been summarized. It is thought that this review will help the reader to find recent studies on the subject.

Original languageEnglish
Article number108340
JournalBiochemical Engineering Journal
Volume180
DOIs
Publication statusPublished - Mar 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier B.V.

Funding

This study is supported by TUBITAK (The Scientific and Technological Research Council of Turkey) 118S108 ( 118S109 ) Grant Numbers.

FundersFunder number
TUBITAK
Türkiye Bilimsel ve Teknolojik Araştirma Kurumu118S108, 118S109

    Keywords

    • Artificial lung
    • Hollow fiber
    • Membrane oxygenation
    • Modification
    • Oxygenator

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