Physical and surface properties of polyurethane hydrogels in relation with their chemical structure

Polyethylene glycol (PEG)/castor oil (CO)-based polyurethanes were prepared by one-shot bulk polymerization method with the potential for biomedical applications. Hexamethylene diisocyanate and 1,4-buthane diol were used as diisocyanate component and chain extender, respectively. Polyurethanes were prepared (1) with crosslinker and catalyst, (2) with crosslinker and without catalyst, and (3) without crosslinker and catalyst. The effects of the ratio of CO to PEG, and presence/absence of the crosslinker and catalyst on some physical and surface properties of the polyurethanes were investigated. The glass transition temperatures of prepared polyurethanes are below room temperature. The swelling ratio increased and the water contact angle decreased with increasing amount of PEG in polymer structure. The samples prepared with crosslinker and without catalyst showed the highest swelling ratio. Gas permeability of the samples was measured in a gas permeability system and surface roughness was determined by scanning electron microscope and atomic force microscope. Protein adsorption studies were performed for the samples synthesized without crosslinker and catalyst by using bovine serum albumin and bovine serum fibrinogen. Unexpected results were obtained for the samples which have low contact angles. They exhibited relatively high protein adsorption. POLYM. ENG. SCI., 54:1182-1191, 2014.