Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates

Mopelola Abidemi Idowu; Solami Xego; Yasin Arslanoglu; John Mark; Edith Antunes; Tebello Nyokong

doi:10.1016/j.saa.2017.12.052

Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates

Mopelola Abidemi Idowu^*, Solami Xego, Yasin Arslanoglu, John Mark, Edith Antunes, Tebello Nyokong

^*Corresponding author for this work

Department of Basic Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Asymmetric Mg (II) or Al (III) phthalocyanine (containing a COOH group and 3-pyridylsulfanyl units) was conjugated via an amide bond to amino functionalized magnetic nanoparticle (AIMN) to form MgPc-AIMN or AlPc-AIMN conjugate, and characterized. The photophysicochemical behaviour of the phthalocyanine–AIMN conjugates was investigated and compared to the asymmetric Pcs and to the simple mixture of Pc with AIMNs without a chemical bond, (MPc-AIMN (mixed)). The directed covalent linkage of AIMNs to the asymmetrical metallopthalocyanines afforded improvements in the singlet oxygen (Ф_Δ) and triplet state quantum yield (Ф_T) as well as singlet oxygen lifetimes for the MPcs–AIMN-linked conjugates compared to MPc-AIMN (mixed) and MPcs alone. The asymmetric phthalocyanines and their conjugates showed effective antimicrobial activity against Escherichia coli bacteria under illumination.

Original language	English
Pages (from-to)	407-414
Number of pages	8
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	193
DOIs	https://doi.org/10.1016/j.saa.2017.12.052
Publication status	Published - 15 Mar 2018

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.

Funding

This work was supported by the Department of Science and Technology (DST) and National Research Foundation (NRF), South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology ( UID 62620 ), as well as Rhodes University . MI thanks FUNAAB for leave. YA thanks Istanbul Technical University, DPT and TUBITAK for leave. This work was supported by the Department of Science and Technology (DST) and National Research Foundation (NRF), South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology (UID 62620), as well as Rhodes University. MI thanks FUNAAB for leave. YA thanks Istanbul Technical University, DPT and TUBITAK for leave.

Funders	Funder number
DST/NRF	UID 62620
National Research Foundation
National Research Foundation
Rhodes University
Department of Science and Technology, Government of Kerala

Keywords

Asymmetric phthalocyanine
Magnetite
Nanoparticles
Photodynamic antimicrobial chemotherapy (PACT)
Singlet oxygen

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10.1016/j.saa.2017.12.052

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title = "Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates",

abstract = "Asymmetric Mg (II) or Al (III) phthalocyanine (containing a COOH group and 3-pyridylsulfanyl units) was conjugated via an amide bond to amino functionalized magnetic nanoparticle (AIMN) to form MgPc-AIMN or AlPc-AIMN conjugate, and characterized. The photophysicochemical behaviour of the phthalocyanine–AIMN conjugates was investigated and compared to the asymmetric Pcs and to the simple mixture of Pc with AIMNs without a chemical bond, (MPc-AIMN (mixed)). The directed covalent linkage of AIMNs to the asymmetrical metallopthalocyanines afforded improvements in the singlet oxygen (ФΔ) and triplet state quantum yield (ФT) as well as singlet oxygen lifetimes for the MPcs–AIMN-linked conjugates compared to MPc-AIMN (mixed) and MPcs alone. The asymmetric phthalocyanines and their conjugates showed effective antimicrobial activity against Escherichia coli bacteria under illumination.",

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Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates. / Idowu, Mopelola Abidemi; Xego, Solami; Arslanoglu, Yasin et al.
In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Vol. 193, 15.03.2018, p. 407-414.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates

AU - Idowu, Mopelola Abidemi

AU - Xego, Solami

AU - Arslanoglu, Yasin

AU - Mark, John

AU - Antunes, Edith

AU - Nyokong, Tebello

PY - 2018/3/15

Y1 - 2018/3/15

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AB - Asymmetric Mg (II) or Al (III) phthalocyanine (containing a COOH group and 3-pyridylsulfanyl units) was conjugated via an amide bond to amino functionalized magnetic nanoparticle (AIMN) to form MgPc-AIMN or AlPc-AIMN conjugate, and characterized. The photophysicochemical behaviour of the phthalocyanine–AIMN conjugates was investigated and compared to the asymmetric Pcs and to the simple mixture of Pc with AIMNs without a chemical bond, (MPc-AIMN (mixed)). The directed covalent linkage of AIMNs to the asymmetrical metallopthalocyanines afforded improvements in the singlet oxygen (ФΔ) and triplet state quantum yield (ФT) as well as singlet oxygen lifetimes for the MPcs–AIMN-linked conjugates compared to MPc-AIMN (mixed) and MPcs alone. The asymmetric phthalocyanines and their conjugates showed effective antimicrobial activity against Escherichia coli bacteria under illumination.

KW - Asymmetric phthalocyanine

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KW - Photodynamic antimicrobial chemotherapy (PACT)

KW - Singlet oxygen

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JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

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ER -

Photophysicochemical behaviour and antimicrobial properties of monocarboxy Mg (II) and Al (III) phthalocyanine-magnetite conjugates

Abstract

Bibliographical note

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Keywords

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