Abstract
The genus Genista L. (Family: Fabaceae) is a plant having several traditional uses for treating common ailments such as diabetes, ulcer, and respiratory diseases. In this current study, the composition of essential oil and the biological activities of Genista sagittalis L. (Fabaceae) from Kocaeli: Yuvacık Dam Basin have been studied. A total of fourteen components were identified in the essential oil. The identified compounds belonged to straight-chain alkane, aromatic ether, and terpenoid derivatives. The antibacterial activity analyses demonstrated that G. sagittalis flower extract only had low activity against P. mirabilis and P. aeruginosa with MICs 1 to 2 mg/mL, as the peduncle extract showed strong anti-QS activity at 1.3 mg/mL. To the best of our knowledge, the current work is the first to report the antimicrobial and anti-quorum sensing activity of G. sagittalis growing in Turkey. Double-stranded DNA binding affinity investigations of the flower and peduncle ethanol extracts indicate that there are interactions with double-stranded DNA and related binding constants (Kb) were found as 1.97 × 103 ± 0.37 and 3.68 × 102 ± 0.44 for the flower and peduncle extract, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 681-691 |
| Number of pages | 11 |
| Journal | Indonesian Journal of Chemistry |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2023 |
Bibliographical note
Publisher Copyright:© 2023, Gadjah Mada University. All rights reserved.
Funding
The authors wish to thank to Istanbul Technical University, Faculty of Sciences and Letters, Department of Chemistry for experimental conditions (Lab L-105 and L2-111 belonging to Prof. Gölcü and Dr. Özdemir respectively) and to Dr. Kübra Erkan Türkmen from Hacettepe University for providing the bacterial strain CV12472. The authors would like to thank the support of the grant of Istanbul Technical University (Scientific Research Projects Unit) under the THD-2023-44771 project. The authors wish to thank to Istanbul Technical University, Faculty of Sciences and Letters, Department of Chemistry for experimental conditions (Lab L-105 and L2-111 belonging to Prof. Gö ̈ and Dr. Özdemir respectively) and to Dr. Kübra Erkan Türkmen from Hacettepe University for providing the bacterial strain CV12472. The authors would like to thank the support of the grant of Istanbul Technical University (Scientific Research Projects Unit) under the THD-2023-44771 project.
| Funders | Funder number |
|---|---|
| Hacettepe Üniversitesi | |
| Istanbul Teknik Üniversitesi | THD-2023-44771 |
Keywords
- anti-quorum sensing
- antibacterial
- DNA binding
- Fabaceae
- Genista sagittalis
- plant extracts
