pH-sensitive castor oil/PEG-based polyurethane films for drug delivery

Fulya Gulmez, Aysima Yercan, Banu Kocaaga, F. Seniha Guner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Apart from the frequent conventional use of polyurethanes (PUs), synthesizing bio-based polyurethanes from renewable sources is a new exciting way. The most intriguing issue in this respect is the use of bio-based PUs in biomedical applications. In the present study, PU films were synthesized from castor oil (CO) and poly(ethylene glycol) (PEG) in different CO:PEG ratios with a different molecular weight of PEG. Procaine was chosen as a model drug. After the characterization of all films by FT-IR, DSC, and SEM methods, they were loaded with the drug in buffer solution at pH 9.1. The drug release behavior of the films in buffer solutions at pH 2.3, 5.8, and 6.4 was determined. Their swelling and degradation behaviors were also determined to explain their drug release mechanism. We found that decreasing the molecular weight of the PEG improved the drug release. Additionally, CO:PEG ratio and medium pH are critical factors for the release behavior of the films. Almost 100% of the total drug was released at pH 2.3 in 24 h, which was approximately more than three-fold than that at pH 6.4. Zero-order, first-order, Higuchi, Korsmeyer-Peppas, and Kopcha kinetic models were used for the evaluation of the release data.

Original languageEnglish
Article number102160
JournalJournal of Drug Delivery Science and Technology
Volume61
DOIs
Publication statusPublished - Feb 2021

Bibliographical note

Publisher Copyright:
© 2020

Funding

The authors thank Gizem Keles (MSc) for assistance in polyurethane synthesis, Serap Durakoglu for contributions to FT-IR and DSC analyses, and Selin Demirci for her support in SEM measurement. This work was funded by Istanbul Technical University Scientific Research Project Foundation (ITU BAP) with Project Numbers 36166 .

FundersFunder number
ITU BAP36166
Istanbul Technical University Scientific Research Project Foundation

    Keywords

    • Castor oil
    • Drug delivery
    • Poly(ethylene glycol)
    • Polyurethane
    • Procaine
    • pH-sensitive polymer

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