Novel high-Throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action

Keyphrases

• HIV-1 Reverse Transcriptase 100%
• Mechanism of Action 100%
• Reverse Transcriptase 100%
• High-throughput Screening 100%
• Unique Mechanism 100%
• Excision 66%
• Signal-to-noise Ratio 33%
• Active Sites 33%
• Methylene 33%
• Drug Discovery 33%
• HIV-1 Susceptibility 33%
• Mechanistic Analysis 33%
• Hydroxybenzoic Acids 33%
• Azidothymidine 33%
• Chemical Library 33%
• Excise 33%
• Polymerase 33%
• Ylidenes 33%
• Förster Resonance Energy Transfer 33%
• DNA Polymerase 33%
• Polymerase Reaction 33%
• Nucleic Acids 33%
• Activity Profile 33%
• Virus Replication 33%
• Reverse Transcription 33%
• Nucleosides 33%
• Drug-resistant HIV 33%
• HIV Drug Resistance 33%
• Drug Resistance 33%
• Monophosphate 33%
• Nucleoside Analogues 33%
• High-throughput Screening Assays 33%
• Drug Inhibitors 33%
• DNA Primers 33%
• Zidovudine 33%
• Z-factor 33%
• Transfer Based 33%

Pharmacology, Toxicology and Pharmaceutical Science

• RNA Directed DNA Polymerase Inhibitor 100%
• RNA Directed DNA Polymerase 100%
• HIV 40%
• Zidovudine 40%
• Nucleic Acid 20%
• Primer DNA 20%
• High-Throughput Screening 20%
• Hydroxybenzoic Acid 20%
• Nucleoside 20%
• Drug Resistance 20%
• DNA Polymerase 20%
• Carbene 20%

Biochemistry, Genetics and Molecular Biology

• Reverse Transcriptase 100%
• Human Immunodeficiency Virus 1 40%
• Zidovudine 40%
• Energy Transfer 20%
• Wild Type 20%
• Polymerase 20%
• Virus Replication 20%
• Reverse Transcription 20%
• Nucleic Acid 20%
• High Throughput Screening 20%
• Signal Noise Ratio 20%
• Active Site 20%
• Drug Resistance 20%
• Nucleoside 20%
• DNA Polymerase 20%