Natural products of relevance in the management of attention deficit hyperactivity disorder

Luísa Custódio; Catarina Vizetto-Duarte; Fatma Cebeci; Beraat Özçelik; Farukh Sharopov; Eda Sönmez Gürer; Manoj Kumar; Marcello Iriti; Javad Sharifi-Rad; Daniela Calina

doi:10.1002/efd2.57

Natural products of relevance in the management of attention deficit hyperactivity disorder

Luísa Custódio, Catarina Vizetto-Duarte, Fatma Cebeci, Beraat Özçelik, Farukh Sharopov, Eda Sönmez Gürer, Manoj Kumar, Marcello Iriti, Javad Sharifi-Rad^*, Daniela Calina^*

^*Corresponding author for this work

Department of Food Engineering

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

Abstract

Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally-occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health-promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants.

Original language	English
Article number	e57
Journal	eFood
Volume	4
Issue number	1
DOIs	https://doi.org/10.1002/efd2.57
Publication status	Published - Feb 2023

Bibliographical note

Publisher Copyright:
© 2022 The Authors. eFood published by John Wiley & Sons Australia, Ltd. on behalf of International Association of Dietetic Nutrition and Safety.

Funding

Luisa Custódio was supported by the FCT Scientific Employment Stimulus (CEECIND/00425/2017). This research received no external funding.

Funders	Funder number
FCT Scientific Employment Stimulus	CEECIND/00425/2017

Keywords

ADHD
clinical studies
natural products
pharmacotherapeutic management
preclinical studies

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10.1002/efd2.57

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abstract = "Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders characterized by motor hyperactivity, attention deficit, distraction, impulsive behavior, and relationship difficulties. It affects children, and thus over the years, there has been growing attention on the use of natural product formulations and their naturally-occurring bioactive for overcoming the problem of ADHD. Concerning this issue, this review aims to discuss the ADHD treatment potential of natural products/formulations in vitro, in vivo as well as in clinical trials. To gather the most relevant data regarding bioactive compounds with potential therapeutic effects in the management of ADHD, the following databases were searched: PubMed/MedLine, ScienceDirect, and Google Scholar for articles in English. Various medicinal plants and their isolated biomolecules have been evaluated in vitro, in vivo, and in clinical trials for their ability to treat ADHD. Most of the analyzed research results showed an improvement of ADHD signs and symptoms in in vivo models, but the molecular mechanisms of action of the bioactive compounds are unclear and incompletely elucidated. Further studies are needed to determine the bioactive compound responsible for health-promoting effects in ADHD. In addition, clinical studies should be performed over longer periods with more participants.",

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AU - Sharopov, Farukh

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Natural products of relevance in the management of attention deficit hyperactivity disorder

Abstract

Bibliographical note

Funding

Keywords

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