Multireactive Poly(2-oxazoline) Nanofibers through Electrospinning with Crosslinking on the Fly

Ozlem I. Kalaoglu-Altan, Bart Verbraeken, Kathleen Lava, Tugce Nihal Gevrek, Rana Sanyal, Tim Dargaville, Karen De Clerck, Richard Hoogenboom*, Amitav Sanyal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Crosslinked hydrophilic poly(2-oxazoline)-based nanofibers amenable to facile multifunctionalization are fabricated using alkene-containing poly(2-alkyl-2-oxazoline)s (PAOx) via in situ photoinitiated radical thiol-ene crosslinking during electrospinning. The resulting crosslinked nanofibers are demonstrated to be multifunctionalizable using different chemistries as they contain two functional handles, being the alkene moieties from the parent copolymer and the residual thiol groups from the tetra-thiol-based crosslinker. While the thiol groups in these nanofibers could be passivated or conjugated to install functional molecules through thiol-maleimide conjugation, the alkene groups could sequentially be modified with thiol-containing molecules using photoinitiated radical thiol-ene reactions. Utilization of the photochemically induced conjugation of thiol-bearing molecules to the alkene groups on the nanofibers is used to obtain functionalization in a spatially controlled manner.

Original languageEnglish
Pages (from-to)676-681
Number of pages6
JournalACS Macro Letters
Volume5
Issue number6
DOIs
Publication statusPublished - 21 Jun 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 American Chemical Society.

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